Phenotypes associated with this allele

• Allele Symbol: Plekho1^tm1Fhe
• Allele Name: targeted mutation 1, Fuchu He
• Allele ID: MGI:3835921
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plekho1^tm1Fhe/Plekho1^tm1Fhe	involves: 129S6/SvEvTac * C57BL/6	MGI:3835932

Genotype
MGI:3835932

hm1

• Allelic Composition: Plekho1^tm1Fhe/Plekho1^tm1Fhe
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoblast physiology ( J:145650 )

• in vitro, bone formation of immature osteoblasts from calvaria bones is increased compared to that of wild-type cells

increased bone mass ( J:145650 )

• between 1 and 12 months of age, mice exhibit an age-dependent increased bone mass as determined by increased bone mineral density and increased ratio of bone volume to tissue volume compared to in wild-type mice

abnormal skeleton development ( J:145650 )

• markers of bone formation are increased in the serum and urine, and mineralized bone nodules are increased in number and size compared to in wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:145650 )

N • despite increased bone volume, mice exhibit normal serum levels of parathyroid hormone, calcium, and phosphorus

cellular

abnormal osteoblast physiology ( J:145650 )

• in vitro, bone formation of immature osteoblasts from calvaria bones is increased compared to that of wild-type cells