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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vsx2tm1(DTA)Kash
targeted mutation 1, Kamal Sharma
MGI:3835936
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Shox2tm1.1(cre)Oki/Shox2+
Tg(CAG-Bgeo/GFP)21Lbe/0
Vsx2tm1(DTA)Kash/Vsx2+ 		involves: 129S/SvEv * 129X1/SvJ * C57BL/6J MGI:5576700


Genotype
MGI:5576700
cn1
Allelic
Composition		 Shox2tm1.1(cre)Oki/Shox2+
Tg(CAG-Bgeo/GFP)21Lbe/0
Vsx2tm1(DTA)Kash/Vsx2+
Genetic
Background		 involves: 129S/SvEv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shox2tm1.1(cre)Oki mutation (0 available); any Shox2 mutation (20 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)
Vsx2tm1(DTA)Kash mutation (0 available); any Vsx2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal spinal cord grey matter morphology ( J:209344 )
• number of Shox2-expressing V2a interneurons is reduced by 98%; total number of Shox2-expressing interneurons is reduced by >80%
abnormal nervous system physiology ( J:209344 )
• variability in locomotor parameters (cycle period, burst duration, amplitude) that are observed in isolated neonatal spinal cords exposed to low NMDA concentrations is increased in mutants compared to controls; higher NMDA concentrations reduce this variability
• other parameters such as burst frequency and flexor-extensor alternation are not significantly different




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory