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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Scgb1a1-rtTA,tetO-Il13)1Eli
transgene insertion 1, Jack A Elias
MGI:3835944
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Il4ratm2Tch/Il4ratm2Tch
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/? 		B6.Cg-Il4ratm2Tch Tg(Scgb1a1-rtTA,tetO-IL13)1Eli MGI:4361939
cx2
 		Tmem219tm1(KOMP)Vlcg/Tmem219tm1(KOMP)Vlcg
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0 		involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA MGI:5903460
cx3
 		Chi3l1tm1Eli/Chi3l1tm1Eli
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0 		involves: C57BL/6 * CBA MGI:3846225
tg4
 		Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0 involves: C57BL/6 * CBA MGI:3846224


Genotype
MGI:4361939
cx1
Allelic
Composition		 Il4ratm2Tch/Il4ratm2Tch
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/?
Genetic
Background		 B6.Cg-Il4ratm2Tch Tg(Scgb1a1-rtTA,tetO-IL13)1Eli
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm2Tch mutation (1 available); any Il4ra mutation (46 available)
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system inflammation ( J:152376 )
• basal airway eosinophilia
increased respiratory mucosa goblet cell number ( J:152376 )
• percentage of goblet cells quadruples in mutant mice upon administration of doxycycline as compared to doubling in the control

immune system
increased eosinophil cell number ( J:152376 )
• basal airway eosinophilia is increased as compared to Q576 IL-13tg control
• administration of doxycycline amplifies difference
respiratory system inflammation ( J:152376 )
• basal airway eosinophilia

hematopoietic system
increased eosinophil cell number ( J:152376 )
• basal airway eosinophilia is increased as compared to Q576 IL-13tg control
• administration of doxycycline amplifies difference




Genotype
MGI:5903460
cx2
Allelic
Composition		 Tmem219tm1(KOMP)Vlcg/Tmem219tm1(KOMP)Vlcg
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
Cell Lines 13990A-E6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli mutation (0 available)
Tmem219tm1(KOMP)Vlcg mutation (1 available); any Tmem219 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
lung inflammation ( J:236976 )
• increased inflammation, mucus metaplasia and bronchoalveolar lavage fluid in mice sensitized and challenged with ovalbumin
pulmonary fibrosis ( J:236976 )
• in mice sensitized and challenged with ovalbumin

immune system
lung inflammation ( J:236976 )
• increased inflammation, mucus metaplasia and bronchoalveolar lavage fluid in mice sensitized and challenged with ovalbumin

homeostasis/metabolism
increased transforming growth factor beta level ( J:236976 )
• increased total and active TGFB1 in the lungs in mice sensitized and challenged with ovalbumin




Genotype
MGI:3846225
cx3
Allelic
Composition		 Chi3l1tm1Eli/Chi3l1tm1Eli
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chi3l1tm1Eli mutation (0 available); any Chi3l1 mutation (29 available)
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T-helper 2 cell number ( J:148490 )
• in mice administered doxycycline, Th2 cell numbers found in the lungs of mice sensitized and challenged with OVA are greater than in wild-type controls but less than in mice carrying just the transgene
abnormal T-helper 2 physiology ( J:148490 )
• in mice administered doxycycline, Th2 responses to OVA sensitization and challenge to the lungs is greater than wild-type controls but less than in mice carrying just the transgene

hematopoietic system
abnormal T-helper 2 cell number ( J:148490 )
• in mice administered doxycycline, Th2 cell numbers found in the lungs of mice sensitized and challenged with OVA are greater than in wild-type controls but less than in mice carrying just the transgene
abnormal T-helper 2 physiology ( J:148490 )
• in mice administered doxycycline, Th2 responses to OVA sensitization and challenge to the lungs is greater than wild-type controls but less than in mice carrying just the transgene




Genotype
MGI:3846224
tg4
Allelic
Composition		 Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T-helper 2 cell number ( J:148490 )
• in mice administered doxycycline, Th2 cell numbers found in the lungs of mice sensitized and challenged with OVA are much greater than in wild-type controls
abnormal T-helper 2 physiology ( J:148490 )
• in mice administered doxycycline, Th2 responses to OVA sensitization and challenge to the lungs is greatly exaggerated compared to wild-type controls

hematopoietic system
increased T-helper 2 cell number ( J:148490 )
• in mice administered doxycycline, Th2 cell numbers found in the lungs of mice sensitized and challenged with OVA are much greater than in wild-type controls
abnormal T-helper 2 physiology ( J:148490 )
• in mice administered doxycycline, Th2 responses to OVA sensitization and challenge to the lungs is greatly exaggerated compared to wild-type controls

respiratory system
pulmonary fibrosis ( J:148490 )
• in mice administered doxycycline, pulmonary fibrosis results in the lungs when mice are sensitized and challenged with OVA




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory