Phenotypes associated with this allele

• Allele Symbol: Tmpo^tm1.1Foi
• Allele Name: targeted mutation 1.1, Roland Foisner
• Allele ID: MGI:3835992
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmpo^tm1.1Foi/Tmpo^tm1.1Foi	involves: 129S1/Sv * C57BL/6	MGI:3836052

Genotype
MGI:3836052

hm1

• Allelic Composition: Tmpo^tm1.1Foi/Tmpo^tm1.1Foi
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle ( J:145628 )

• primary fibroblasts have a defect in contact-mediated cell cycle arrest with cells reaching a density 1.5-fold greater than controls

abnormal enterocyte proliferation ( J:145628 )

• 20% more epithelial cells are actively proliferating in the colon epithelium

digestive/alimentary system

abnormal enterocyte proliferation ( J:145628 )

• 20% more epithelial cells are actively proliferating in the colon epithelium

abnormal large intestine crypts of Lieberkuhn morphology ( J:145628 )

• crypt lengths are significantly increased in mice

limbs/digits/tail

abnormal autopod morphology ( J:145628 )

• there is a 20% increase in the thickness of the epidermis located in the plantar region of the paw

• the number of proliferating cells in the paw epidermis is increased two-fold compared to controls

hematopoietic system

increased erythroid progenitor cell number ( J:145628 )

• spleens have up to a four-fold increase in erythroid progenitors

• bone marrow contains about 30% more erythroid progenitors

• in mice treated with phenylhydrazine, there are 20% more erythroid progenitors in the spleen than wild-type mice two days after injection

increased hematocrit ( J:145628 )

• hematocrit is slightly but significantly increased from 52.8% to 56.5%

• in mice treated with phenylhydrazine, hematocrit levels recover after 5 days compared to 7 days for wild-type controls

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:145628 )

• crypt lengths are significantly increased in mice

integument

thick epidermis ( J:145628 )

• there is a 20% increase in the thickness of the epidermis located in the plantar region of the paw