Phenotypes associated with this allele

• Allele Symbol: Vsx2^{tm1.1(DTA)Kash}
• Allele Name: targeted mutation 2.1, Kamal Sharma
• Allele ID: MGI:3836012
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Vsx2^tm1.1(DTA)Kash/Vsx2^+	involves: 129S4/SvJae * C57BL/6	MGI:3836039

Genotype
MGI:3836039

ht1

• Allelic Composition: Vsx2^{tm1.1(DTA)Kash}/Vsx2⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:145621 )

• mice die within 24 hours of birth likely due to respiratory defects

nervous system

abnormal spinal cord interneuron morphology ( J:145621 )

• at E11.5, Vsx2+ spinal cords contain 57% fewer neurons than in wild-type mice, and by P0 no Chx+ interneurons are detected in the spinal cord

• at E13.5, Vsx2+ interneurons are reduced 4-fold compared to in wild-type mice with only newly generated Vsx2+ interneurons remaining in medial locations

• at P0, ventral vGlut2+ (Slc17a6+) neurons are decreased 30% compared to in wild-type mice

abnormal ventral interneuron 2 morphology ( J:145621 )

• V2a class excitatory interneurons are ablated

abnormal nervous system physiology ( J:145621 )

• the variability in burst amplitude and cycle period are greater in spinal cords and exhibit increased variability over additional cycles compared to in wild-type mice indicating that locomotor rhythms are destabilized

• however, commissurally projecting inhibitory glycinergic interneuron signaling, chemically-induced intrinsic rhythmogenic activity of spinal cord interneurons, and ipsilateral flexor-extensor alternations are normal

• signaling of left-right coordination is disrupted in the spinal cord compared to in wild-type mice

• neurally evoked locomotor rhythm initiation by the brainstem or sensory afferents is inhibited unlike in wild-type mice