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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(MMTV-AURKA)#Cxd
transgene insertion, Chu-Xia Deng
MGI:3836060
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(MMTV-AURKA)#Cxd/?
Trp53tm1Tyj/Trp53+ 		involves: 129S2/SvPas * FVB/N MGI:3836158
tg2
 		Tg(MMTV-AURKA)#Cxd/? involves: FVB/N MGI:3836157


Genotype
MGI:3836158
cx1
Allelic
Composition		 Tg(MMTV-AURKA)#Cxd/?
Trp53tm1Tyj/Trp53+
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-AURKA)#Cxd mutation (0 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:145680 )
• mammary tumors start to develop at 6 months of age
• 70% of mice have developed tumors by 18 months of age

cellular
polyploidy ( J:145680 )
• 25% of mammary epithelial cells from 4-month old mice are polyploidy and show premature chromatid segregation
• about half of mammary epithelial tumor cells are polyploidy

endocrine/exocrine glands
abnormal mammary gland epithelium morphology ( J:145680 )
• 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice
abnormal branching of the mammary ductal tree ( J:145680 )
• parous mice over one year in age have more extensive ductal branching than transgenic mice not carrying a mutant Trp53 allele
mammary gland duct hyperplasia ( J:145680 )
• parous mice have almost 6-fold more actively proliferating cells in the mammary epithelium than in controls
increased mammary adenocarcinoma incidence ( J:145680 )
• mammary tumors start to develop at 6 months of age
• 70% of mice have developed tumors by 18 months of age

integument
abnormal mammary gland epithelium morphology ( J:145680 )
• 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice
abnormal branching of the mammary ductal tree ( J:145680 )
• parous mice over one year in age have more extensive ductal branching than transgenic mice not carrying a mutant Trp53 allele
mammary gland duct hyperplasia ( J:145680 )
• parous mice have almost 6-fold more actively proliferating cells in the mammary epithelium than in controls
increased mammary adenocarcinoma incidence ( J:145680 )
• mammary tumors start to develop at 6 months of age
• 70% of mice have developed tumors by 18 months of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:145680




Genotype
MGI:3836157
tg2
Allelic
Composition		 Tg(MMTV-AURKA)#Cxd/?
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:145680 )
• mice that have given birth at least 5 times have increased risk of developing mammary tumors
• tumors first become visible at 9 months of age
• about 40% of mice develop mammary tumors consisting of adenocarcinomas or spindle cell carcinoma
• in contrast only about 8% of virgin mice develop mammary tumors over a two-year time frame
increased ovary tumor incidence ( J:145680 )
• is noted in about 3% of mice that have given birth at least 5 times
increased kidney tumor incidence ( J:145680 )
• kidney tumor is observed in about 3% of mice that have given birth at least 5 times

cellular
polyploidy ( J:145680 )
• 25% of mammary epithelial cells from 4-month old mice are polyploidy and show premature chromatid segregation
• about half of mammary epithelial tumor cells are polyploidy

endocrine/exocrine glands
abnormal mammary gland epithelium morphology ( J:145680 )
• 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice
abnormal branching of the mammary ductal tree ( J:145680 )
• parous mice over one year in age have more extensive ductal branching
mammary gland duct hyperplasia ( J:145680 )
• mammary glands are visibly larger at 4 month of age
mammary gland alveolar hyperplasia ( J:145680 )
• parous mice over one year in age have increased alveolization within the gland
increased mammary adenocarcinoma incidence ( J:145680 )
• mice that have given birth at least 5 times have increased risk of developing mammary tumors
• tumors first become visible at 9 months of age
• about 40% of mice develop mammary tumors consisting of adenocarcinomas or spindle cell carcinoma
• in contrast only about 8% of virgin mice develop mammary tumors over a two-year time frame
mammary gland hyperplasia ( J:145680 )
• mammary epithelium at 2 months of age exhibit multiple layers of cells in contrast to the one or two cell layers found in control mice
• parous mice have 4-fold more actively proliferating cells in the mammary epithelium than controls
increased ovary tumor incidence ( J:145680 )
• is noted in about 3% of mice that have given birth at least 5 times

reproductive system
increased ovary tumor incidence ( J:145680 )
• is noted in about 3% of mice that have given birth at least 5 times
uterus hyperplasia ( J:145680 )
• is observed in mice that have given birth multiple times

integument
abnormal mammary gland epithelium morphology ( J:145680 )
• 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice
abnormal branching of the mammary ductal tree ( J:145680 )
• parous mice over one year in age have more extensive ductal branching
mammary gland duct hyperplasia ( J:145680 )
• mammary glands are visibly larger at 4 month of age
mammary gland alveolar hyperplasia ( J:145680 )
• parous mice over one year in age have increased alveolization within the gland
increased mammary adenocarcinoma incidence ( J:145680 )
• mice that have given birth at least 5 times have increased risk of developing mammary tumors
• tumors first become visible at 9 months of age
• about 40% of mice develop mammary tumors consisting of adenocarcinomas or spindle cell carcinoma
• in contrast only about 8% of virgin mice develop mammary tumors over a two-year time frame
mammary gland hyperplasia ( J:145680 )
• mammary epithelium at 2 months of age exhibit multiple layers of cells in contrast to the one or two cell layers found in control mice
• parous mice have 4-fold more actively proliferating cells in the mammary epithelium than controls

renal/urinary system
increased kidney tumor incidence ( J:145680 )
• kidney tumor is observed in about 3% of mice that have given birth at least 5 times

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:145680




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory