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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm3Mnz
targeted mutation 3, Michel C Nussenzweig
MGI:3836312
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ightm3Mnz/Ightm4.1Mnz involves: C57BL/6 MGI:4452375
cn2
 		Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Ightm4.1Mnz
Trp53bp1tm1Jc/Trp53bp1tm1Jc 		involves: 129 * C57BL/6 * CBA MGI:4452376
cn3
 		Aicdatm1(cre)Mnz/Aicda+
Ightm3Mnz/Igh+
Myctm39Mnz/Myc+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3836396
cn4
 		Aicdatm1(cre)Mnz/Aicda+
Ightm3Mnz/Igh+
Myctm37Mnz/Myc+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3836397
cx5
 		Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Igh+
Myctm37Mnz/Myc+ 		involves: C57BL/6 * CBA MGI:3836398


Genotype
MGI:4452375
ht1
Allelic
Composition		 Ightm3Mnz/Ightm4.1Mnz
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm3Mnz mutation (1 available); any Igh mutation (44 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:159173 )
N
• mice exhibit normal B cell development and class switch recombination to IgG1 following stimulation with LPS and IL4




Genotype
MGI:4452376
cn2
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Ightm4.1Mnz
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Ightm3Mnz mutation (1 available); any Igh mutation (44 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (44 available)
Trp53bp1tm1Jc mutation (1 available); any Trp53bp1 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal class switch recombination ( J:159173 )
• I-SceI mediated class switch recombination in LPS- and IL4-stimulated B cells is decreased compared to similarly treated Aicdatm1Hon/Aicdatm1Hon Ightm3Mnz/Ightm4.1Mnz B cells

immune system
abnormal class switch recombination ( J:159173 )
• I-SceI mediated class switch recombination in LPS- and IL4-stimulated B cells is decreased compared to similarly treated Aicdatm1Hon/Aicdatm1Hon Ightm3Mnz/Ightm4.1Mnz B cells




Genotype
MGI:3836396
cn3
Allelic
Composition		 Aicdatm1(cre)Mnz/Aicda+
Ightm3Mnz/Igh+
Myctm39Mnz/Myc+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1(cre)Mnz mutation (1 available); any Aicda mutation (57 available)
Ightm3Mnz mutation (1 available); any Igh mutation (44 available)
Myctm39Mnz mutation (1 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
spontaneous chromosome breakage ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

immune system
abnormal B cell physiology ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

hematopoietic system
abnormal B cell physiology ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles




Genotype
MGI:3836397
cn4
Allelic
Composition		 Aicdatm1(cre)Mnz/Aicda+
Ightm3Mnz/Igh+
Myctm37Mnz/Myc+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1(cre)Mnz mutation (1 available); any Aicda mutation (57 available)
Ightm3Mnz mutation (1 available); any Igh mutation (44 available)
Myctm37Mnz mutation (1 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
spontaneous chromosome breakage ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

immune system
abnormal B cell physiology ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

hematopoietic system
abnormal B cell physiology ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles




Genotype
MGI:3836398
cx5
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Igh+
Myctm37Mnz/Myc+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Ightm3Mnz mutation (1 available); any Igh mutation (44 available)
Myctm37Mnz mutation (1 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
induced chromosome breakage ( J:145691 )
• activated B cells transfected with yeast-derived I-SceI endonuclease have a high incidence of chromosomal translocations involving chromosomes 12 and 15
• chromosome fusions occur within 2.2 kb of the I-SceI recognition sites that are present in the Myc and Igh mutant alleles
• out of 21 translocation junctions, 19 involved 1-7 bps of microhomology (average microhomology of 2.9 bps) and two included insertions
• translocation rates are similar when B cells are transfected with Aicda, cre, or SceI genes




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory