Analysis Tools
mortality/aging
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• disrupt embryonic development and caused embryonic lethality between E11 and E13
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nervous system
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• the basal plates of the midbrain are flat in homozygous mutants with exencephaly
• normal cells expressing Foxa2 in the floor plate are missing in spinal cord
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• tight mesencephalic flexure in mutant embryos that undergo neural tube closure
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exencephaly
(
J:142506
)
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• some homozygous mutants exhibit exencephaly in the midbrain and posterior forebrain
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embryo
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• primary cilia failed to form in most cells in the ventral embryonic node
• primary cilia formation in MEF derived from mutant embryo was greatly compromised
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• dorsal-ventral patterning of the CNS is disrupted
• loss of ventral cell types in the spinal cord and a ventral expansion of more lateral cell types
• less severe loss of ventral cell types than homozygous C2cd3Gt(AG0177)Wtsi
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• loss of left-right asymmetry
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• twisted body axis
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• the basal plates of the midbrain are flat in homozygous mutants with exencephaly
• normal cells expressing Foxa2 in the floor plate are missing in spinal cord
|
cardiovascular system
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• the heart loop turns to opposite direction of the wild type
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homeostasis/metabolism
limbs/digits/tail
polydactyly
(
J:142506
)
|
• exhibit severe polydactyly in all four limbs at E12.5
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cellular
|
• primary cilia failed to form in most cells in the ventral embryonic node
• primary cilia formation in MEF derived from mutant embryo was greatly compromised
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