Phenotypes associated with this allele

• Allele Symbol: Phf13^Gt(XB691)Byg
• Allele Name: gene trap XB691, BayGenomics
• Allele ID: MGI:3836461
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Phf13^Gt(XB691)Byg/Phf13^Gt(XB691)Byg	B6.129P2-Phf13^Gt(XB691)Byg	MGI:5430758
hm2	Phf13^Gt(XB691)Byg/Phf13^Gt(XB691)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5430757

Genotype
MGI:5430758

hm1

• Allelic Composition: Phf13^Gt(XB691)Byg/Phf13^Gt(XB691)Byg
• Genetic Background: B6.129P2-Phf13^Gt(XB691)Byg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal spermatogenesis ( J:185876 )

♂ • Background Sensitivity: more severe than in mice on a mixed background

Genotype
MGI:5430757

hm2

• Allelic Composition: Phf13^Gt(XB691)Byg/Phf13^Gt(XB691)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:185876 )

• between E13.5 and E15.5

perinatal lethality, incomplete penetrance ( J:185876 )

postnatal lethality, incomplete penetrance ( J:185876 )

• early

embryonic lethality during organogenesis, incomplete penetrance ( J:185876 )

• between E13.5 and E15.5

reproductive system

abnormal male germ cell apoptosis ( J:185876 )

♂

abnormal seminiferous tubule morphology ( J:185876 )

♂ • disorganized at 10 weeks

small testis ( J:185876 )

♂

decreased testis weight ( J:185876 )

♂ • at 5 weeks

testicular atrophy ( J:185876 )

♂ • completely by 20 weeks

abnormal spermatogenesis ( J:185876 )

♂ • mice exhibit a break-down in spermatogenesis

♂ • mice exhibit abnormal spatial distribution and impaired differentiation of spermatogonial stem cells compared with wild-type mice

♂ • Background Sensitivity: less severe than in mice on a congenic C57BL/6 background

♂ • however, mice exhibit normal numbers of gonocytes and Sertoli cells

oligozoospermia ( J:185876 )

♂ • at 5, 10 and 20 weeks

reduced male fertility ( J:185876 )

♂ • after 5 weeks, male mice exhibit reproductive defects and require a substantially prolonged period of time to impregnate female mice compared with wild-type mice

cellular

oligozoospermia ( J:185876 )

♂ • at 5, 10 and 20 weeks

abnormal male germ cell apoptosis ( J:185876 )

♂

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:185876 )

♂ • disorganized at 10 weeks

small testis ( J:185876 )

♂

decreased testis weight ( J:185876 )

♂ • at 5 weeks

testicular atrophy ( J:185876 )

♂ • completely by 20 weeks