All Phenotypes Traf6<tm1.1Mpa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Traf6^tm1.1Mpa
targeted mutation 1.1, Manolis Pasparakis
MGI:3836555

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Traf6^tm1.1Mpa/Traf6^tm1.1Mpa Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3837131

Allelic Composition	Traf6^tm1.1Mpa/Traf6^tm1.1Mpa Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Traf6^tm1.1Mpa mutation (0 available); any Traf6 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased circulating interleukin-6 level ( J:145306 )

• following exposure to acid-induced acute lung injury

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:145306 )

• following exposure to acid-induced acute lung injury

decreased susceptibility to injury ( J:145306 )

• following exposure to acid-induced acute lung injury, mice exhibit alleviated symptoms compared to wild-type mice with decreased changes in elastance and serum IL6 levels

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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