All Phenotypes Tg(IGH-Btk)1Witt MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Blnk^tm1Achn/Blnk⁺ Btk^tm1Wk/Btk^tm1Wk Tg(IGH-Btk)1Witt/0	involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6	MGI:3836561
cx2	Btk^tm1Wk/Btk^tm1Wk Tg(IGH-Btk)1Witt/0	involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6	MGI:3836562
cx3	Btk^xid/? Tg(IGH-Btk)1Witt/0	involves: BALB/c * C3H * C57BL/6 * CBA/N	MGI:3836568
cx4	Btk^xid/? Tg(IGH-Btk)1Witt/Tg(IGH-Btk)1Witt	involves: BALB/c * C3H * C57BL/6 * CBA/N	MGI:3836569

Allelic Composition	Blnk^tm1Achn/Blnk⁺ Btk^tm1Wk/Btk^tm1Wk Tg(IGH-Btk)1Witt/0
Genetic Background	involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnk^tm1Achn mutation (1 available); any Blnk mutation (78 available)
Btk^tm1Wk mutation (1 available); any Btk mutation (21 available)
Tg(IGH-Btk)1Witt mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:82430 )

• impairment in the early and late phases of Ca²⁺ mobilization following BCR stimulation

decreased B cell proliferation ( J:82430 )

• fail to proliferate after BCR cross linking

• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

hematopoietic system

abnormal B cell physiology ( J:82430 )

• impairment in the early and late phases of Ca²⁺ mobilization following BCR stimulation

decreased B cell proliferation ( J:82430 )

• fail to proliferate after BCR cross linking

• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

cellular

decreased B cell proliferation ( J:82430 )

• fail to proliferate after BCR cross linking

• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

Allelic Composition	Btk^tm1Wk/Btk^tm1Wk Tg(IGH-Btk)1Witt/0
Genetic Background	involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btk^tm1Wk mutation (1 available); any Btk mutation (21 available)
Tg(IGH-Btk)1Witt mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell proliferation ( J:82430 )

• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

hematopoietic system

decreased B cell proliferation ( J:82430 )

• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

cellular

decreased B cell proliferation ( J:82430 )

• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

Allelic Composition	Btk^xid/? Tg(IGH-Btk)1Witt/0
Genetic Background	involves: BALB/c * C3H * C57BL/6 * CBA/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btk^xid mutation (3 available); any Btk mutation (21 available)
Tg(IGH-Btk)1Witt mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell proliferation ( J:108696 )

• less sensitive to anti-IgM induced proliferation compared to wild-type controls

decreased B-1 B cell number ( J:108696 )

• the percentage of peritoneal B220+CD5+ cells is decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene

• however, the frequency and number of splenic B cells are similar to wild-type controls

decreased IgG3 level ( J:108696 )

• basal serum IgG3 levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene

decreased IgM level ( J:108696 )

• serum levels of IgM following TNP-Ficoll treatment are reduced compared to wild-type controls

• basal serum IgM levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene

hematopoietic system

decreased B cell proliferation ( J:108696 )

• less sensitive to anti-IgM induced proliferation compared to wild-type controls

decreased B-1 B cell number ( J:108696 )

• the percentage of peritoneal B220+CD5+ cells is decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene

• however, the frequency and number of splenic B cells are similar to wild-type controls

decreased IgG3 level ( J:108696 )

• basal serum IgG3 levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene

decreased IgM level ( J:108696 )

• serum levels of IgM following TNP-Ficoll treatment are reduced compared to wild-type controls

• basal serum IgM levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene

cellular

decreased B cell proliferation ( J:108696 )

• less sensitive to anti-IgM induced proliferation compared to wild-type controls

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell proliferation ( J:108696 )

• less sensitive to anti-IgM induced proliferation compared to wild-type controls but more responsive than mutant mice hemizygous for the transgene

decreased B-1 B cell number ( J:108696 )

• in most mice the percentage of peritoneal B220+CD5+ cells is decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene

• however, some mice had frequencies of B1 cells near the normal range

• the frequency and number of splenic B cells are similar to wild-type controls

decreased IgG3 level ( J:108696 )

• basal serum IgG3 levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene

decreased IgM level ( J:108696 )

• serum levels of IgM following TNP-Ficoll treatment are reduced compared to wild-type controls

• basal serum IgM levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene

hematopoietic system

decreased B cell proliferation ( J:108696 )

• less sensitive to anti-IgM induced proliferation compared to wild-type controls but more responsive than mutant mice hemizygous for the transgene

decreased B-1 B cell number ( J:108696 )

• in most mice the percentage of peritoneal B220+CD5+ cells is decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene

• however, some mice had frequencies of B1 cells near the normal range

• the frequency and number of splenic B cells are similar to wild-type controls

decreased IgG3 level ( J:108696 )

• basal serum IgG3 levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene

decreased IgM level ( J:108696 )

• serum levels of IgM following TNP-Ficoll treatment are reduced compared to wild-type controls

• basal serum IgM levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene

cellular

decreased B cell proliferation ( J:108696 )

• less sensitive to anti-IgM induced proliferation compared to wild-type controls but more responsive than mutant mice hemizygous for the transgene

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