All Phenotypes Cdc25a<tm1.1Hpw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cdc25a^tm1.1Hpw
targeted mutation 1, Helen Piwnica-Worms
MGI:3836586

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdc25a^tm1.1Hpw/Cdc25a^tm1.1Hpw	involves: 129X1/SvJ * C57BL/6	MGI:3845381
cn2	Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	MGI:3845383
cn3	Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Cdc25b^tm1Pjd/Cdc25b^tm1Pjd Cdc25c^tm1Hpw/Cdc25c^tm1Hpw Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	MGI:3845392
cn4	Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Tg(Vil1-cre/ERT2)23Syr/0	involves: 129X1/SvJ * C57BL/6 * DBA/2	MGI:4941915
cn5	Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Cdc25c^tm1Hpw/Cdc25c^tm1Hpw Tg(Vil1-cre/ERT2)23Syr/0	involves: 129X1/SvJ * C57BL/6 * DBA/2	MGI:4941916
cn6	Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Cdc25b^tm1Pjd/Cdc25b^tm1Pjd Tg(Vil1-cre/ERT2)23Syr/0	involves: 129X1/SvJ * C57BL/6 * DBA/2	MGI:4941917
cn7	Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Cdc25b^tm1Pjd/Cdc25b^tm1Pjd Cdc25c^tm1Hpw/Cdc25c^tm1Hpw Tg(Vil1-cre/ERT2)23Syr/0	involves: 129X1/SvJ * C57BL/6 * DBA/2	MGI:4941918

Allelic Composition	Cdc25a^tm1.1Hpw/Cdc25a^tm1.1Hpw
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc25a^tm1.1Hpw mutation (1 available); any Cdc25a mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cdc25a^tm1.1Hpw/Cdc25a^tm1.1Hpw embryos undergo apoptosis during postimplantation development

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:145768 )

• embryos die before E7.5 with most embryos resorbed by this time; occasional embryos survive to E6.5

embryo

embryonic growth retardation ( J:145768 )

• embryos exhibit severe growth abnormalities by E6.5-7.5

abnormal inner cell mass morphology ( J:145768 )

• isolated blastocysts are unable to expand their inner cell mass in culture

growth/size/body

embryonic growth retardation ( J:145768 )

• embryos exhibit severe growth abnormalities by E6.5-7.5

cellular

increased apoptosis ( J:145768 )

• significant apoptosis is detected by E7.5

Allelic Composition	Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:145768 )

N	• no difference in villi height is after 4-hydroxytamoxifen treatment observed after in contrast to triple knockout mice

Allelic Composition	Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Cdc25b^tm1Pjd/Cdc25b^tm1Pjd Cdc25c^tm1Hpw/Cdc25c^tm1Hpw Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc25a^tm1.1Hpw mutation (1 available); any Cdc25a mutation (34 available)
Cdc25a^tm1Hpw mutation (1 available); any Cdc25a mutation (34 available)
Cdc25b^tm1Pjd mutation (0 available); any Cdc25b mutation (30 available)
Cdc25c^tm1Hpw mutation (1 available); any Cdc25c mutation (23 available)
Gt(ROSA)26Sor^{tm1(cre/ERT)Brn} mutation (1 available); any Gt(ROSA)26Sor mutation (992 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Shortened villi in the small intestine of Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Cdc25b^tm1Pjd/Cdc25b^tm1Pjd Cdc25c^tm1Hpw/Cdc25c^tm1Hpw Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺ (TKO) mice

mortality/aging

premature death ( J:145768 )

• adult mice die within 1 week of initial 4-hydroxytamoxifen (OHT) injection

growth/size/body

weight loss ( J:145768 )

• adult mice exhibit significant weight loss (20%) within 1 week of initial tamoxifen injection

digestive/alimentary system

abnormal small intestine crypts of Lieberkuhn morphology ( J:145768 )

• profound cell atrophy in the crypts is observed in OHT-treated mice; crypts are >40% smaller in mutants than Cdc25a-single knockout controls, with the crypt width being decreased more significantly than the depth

• a 70% loss of epithelial cells per crypt is detected, but no difference in mature Paneth cells is observed

• decreased proliferation of epithelial cells is observed, with no significant increase in apoptotic cell numbers; this results in premature differentiation of cell progenitors below Paneth cell compartments in crypts

• crypts have increased numbers of cells exhibiting early differentiation with no crypt base columnar (CBC) cells

abnormal small intestinal villus morphology ( J:145768 )

• villi are lined with shorter, less-dense enterocytes in proximal regions; complete loss of distal villi is observed in some areas

decreased small intestinal villus height ( J:145768 )

• significant loss of villus height in proximal and distal regions is observed in mutants after OHT treatment

decreased small intestine length ( J:145768 )

• 6 days following the final of 3 consecutive injections of tamoxifen, length of small intestine is shortened by 40% compared to controls

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:145768 )

• a 70% loss of epithelial cells per crypt is detected, but no difference in mature Paneth cells is observed

• crypts have increased numbers of cells exhibiting early differentiation with no crypt base columnar (CBC) cells

Allelic Composition	Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Tg(Vil1-cre/ERT2)23Syr/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal large intestine morphology ( J:169457 )

• mild reduction in length in tamoxifen-treated mice

abnormal small intestine morphology ( J:169457 )

• mild reduction in length in tamoxifen-treated mice

growth/size/body

growth/size/body region phenotype ( J:169457 )

N	• tamoxifen-treated mice exhibit normal body weight

Allelic Composition	Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Cdc25c^tm1Hpw/Cdc25c^tm1Hpw Tg(Vil1-cre/ERT2)23Syr/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc25a^tm1.1Hpw mutation (1 available); any Cdc25a mutation (34 available)
Cdc25a^tm1Hpw mutation (1 available); any Cdc25a mutation (34 available)
Cdc25c^tm1Hpw mutation (1 available); any Cdc25c mutation (23 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:169457 )

N	• tamoxifen-treated mice exhibit normal intestine morphology

growth/size/body

growth/size/body region phenotype ( J:169457 )

N	• tamoxifen-treated mice exhibit normal body weight

Allelic Composition	Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Cdc25b^tm1Pjd/Cdc25b^tm1Pjd Tg(Vil1-cre/ERT2)23Syr/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:169457 )

• 2 of 5 tamoxifen-treated mice die by day 8

digestive/alimentary system

increased enterocyte apoptosis ( J:169457 )

• in tamoxifen-treated mice

abnormal enterocyte differentiation ( J:169457 )

• tamoxifen-treated mice exhibit premature differentiation of small intestine crypt cells compared with control mice

abnormal small intestinal crypt cell proliferation ( J:169457 )

• tamoxifen-treated mice exhibit decreased S-phase cells in crypts compared with control mice

abnormal large intestine morphology ( J:169457 )

• reduced length in tamoxifen-treated mice

abnormal small intestine morphology ( J:169457 )

• reduced length in tamoxifen-treated mice

abnormal small intestine crypts of Lieberkuhn morphology ( J:169457 )

• tamoxifen treated mice exhibit a reduction in epithelium cells in the small intestine crypts compared with control mice

• however, the number of Paneth cells is normal

decreased small intestinal villus size ( J:169457 )

• in tamoxifen-treated mice

growth/size/body

decreased body weight ( J:169457 )

• in tamoxifen-treated mice

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:169457 )

• however, the number of Paneth cells is normal

• tamoxifen treated mice exhibit a reduction in epithelium cells in the small intestine crypts compared with control mice

cellular

increased enterocyte apoptosis ( J:169457 )

• in tamoxifen-treated mice

abnormal enterocyte differentiation ( J:169457 )

• tamoxifen-treated mice exhibit premature differentiation of small intestine crypt cells compared with control mice

abnormal small intestinal crypt cell proliferation ( J:169457 )

• tamoxifen-treated mice exhibit decreased S-phase cells in crypts compared with control mice

Allelic Composition	Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Cdc25b^tm1Pjd/Cdc25b^tm1Pjd Cdc25c^tm1Hpw/Cdc25c^tm1Hpw Tg(Vil1-cre/ERT2)23Syr/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:169457 )

• 5 of 11 tamoxifen-treated mice die by day 8

digestive/alimentary system

increased enterocyte apoptosis ( J:169457 )

• in tamoxifen-treated mice

abnormal enterocyte differentiation ( J:169457 )

• tamoxifen-treated mice exhibit premature differentiation of small intestine crypt cells compared with control mice

abnormal small intestinal crypt cell proliferation ( J:169457 )

• tamoxifen-treated mice exhibit decreased S-phase cells in crypts compared with control mice

abnormal large intestine morphology ( J:169457 )

• reduced length in tamoxifen-treated mice

abnormal small intestine morphology ( J:169457 )

• reduced length in tamoxifen-treated mice

abnormal small intestine crypts of Lieberkuhn morphology ( J:169457 )

• tamoxifen treated mice exhibit a reduction in epithelium cells in the small intestine crypts compared with control mice

• however, the number of Paneth cells is normal

decreased small intestinal villus size ( J:169457 )

• in tamoxifen-treated mice

growth/size/body

decreased body weight ( J:169457 )

• in tamoxifen-treated mice

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:169457 )

• tamoxifen treated mice exhibit a reduction in epithelium cells in the small intestine crypts compared with control mice

• however, the number of Paneth cells is normal

cellular

increased enterocyte apoptosis ( J:169457 )

• in tamoxifen-treated mice

abnormal enterocyte differentiation ( J:169457 )

• tamoxifen-treated mice exhibit premature differentiation of small intestine crypt cells compared with control mice

abnormal small intestinal crypt cell proliferation ( J:169457 )

• tamoxifen-treated mice exhibit decreased S-phase cells in crypts compared with control mice

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