Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-AIP/PLN*)46Jded
• Allele Name: transgene insertion 46, John R Dedman
• Allele ID: MGI:3836606
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-AIP/PLN*)46Jded/0	FVB/N-Tg(Myh6-AIP/PLN*)46Jded	MGI:4362062

Genotype
MGI:4362062

tg1

• Allelic Composition: Tg(Myh6-AIP/PLN*)46Jded/0
• Genetic Background: FVB/N-Tg(Myh6-AIP/PLN*)46Jded

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tg(Myh6-AIP/PLN*)46Jded/0 females producing at least 3 litters develop cardiac hypertrophy and dilated heart failure

cardiovascular system

abnormal heart atrium morphology ( J:84333 )

• multiple large thrombi are found in atrial lumen of 7 month old females that have produced at least three litters

• recanalization and myocyte hypertrophy are observed in 7 month old females that have produced at least three litters

increased heart left atrium size ( J:84333 )

• observed in 7 month old females that have produced at least three litters

increased heart weight ( J:84333 )

• 2.82-fold increase observed in 7 month old females that have produced at least three litters

cardiac hypertrophy ( J:84333 )

• although not observed in 3-4 month old mice, hypertrophy is found in 7 month old females that have produced at least three litters

abnormal heart ventricle morphology ( J:84333 )

• myocyte hypertrophy is observed in 7 month old females that have produced at least three litters

increased heart left ventricle size ( J:84333 )

• observed in 7 month old females that have produced at least three litters

cardiac fibrosis ( J:84333 )

• observed in left atrium and ventricle of 7 month old females that have produced at least three litters

abnormal cardiac muscle relaxation ( J:84333 )

• cardiac relaxation is 26% slower in transgenic mice

increased left ventricle diastolic pressure ( J:84333 )

• left ventricle end diastolic pressure (LVEDP) is higher in transgenic mice

increased left ventricle systolic pressure ( J:84333 )

decreased heart rate ( J:84333 )

• mice exhibit a decreased heart rate under basal and stimulated conditions

increased heart rate ( J:84333 )

• maximal heart response is increased in response to dobutamine as compared to control

congestive heart failure ( J:84333 )

• dilated heart failure is observed in 7 month old females that have produced at least three litters and in 12-14 month old males

muscle

abnormal cardiac muscle relaxation ( J:84333 )

• cardiac relaxation is 26% slower in transgenic mice

respiratory system

increased lung weight ( J:84333 )

• 2.87-fold increase observed in 7 month old females that have produced at least three litters

growth/size/body

increased heart weight ( J:84333 )

• 2.82-fold increase observed in 7 month old females that have produced at least three litters

cardiac hypertrophy ( J:84333 )

• although not observed in 3-4 month old mice, hypertrophy is found in 7 month old females that have produced at least three litters

increased lung weight ( J:84333 )

• 2.87-fold increase observed in 7 month old females that have produced at least three litters