Phenotypes associated with this allele

• Allele Symbol: Tg(Drd1-cre)EY262Gsat
• Allele Name: transgene insertion EY262, GENSAT Project at Rockefeller University
• Allele ID: MGI:3836631
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ehmt2^tm1.1Tara/Ehmt2^tm1.1Tara Tg(Drd1-cre)EY262Gsat/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:4418568
cn2	Nlgn3^tm4.1Sud/Y Tg(Drd1-cre)EY262Gsat/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL	MGI:5660864
cn3	Nlgn3^tm1Sud/Y Tg(Drd1-cre)EY262Gsat/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5660866
cn4	Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Drd1-cre)EY262Gsat/0	involves: BALB/cJ * C57BL/6J * FVB/N	MGI:5563804
cn5	Ppp1r1b^tm5.1Pggd/Ppp1r1b^tm5.1Pggd Tg(Drd1-cre)EY262Gsat/0 Tg(Drd1-EGFP)X60Gsat/0	involves: C57BL/6 * FVB/N * FVB/NTac	MGI:4830459

Genotype
MGI:4418568

cn1

• Allelic Composition: Ehmt2^tm1.1Tara/Ehmt2^tm1.1Tara; Tg(Drd1-cre)EY262Gsat/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to xenobiotic ( J:155739 )

• decrease in Drd-1 agonist SKE 81291 induced locomotor and exploratory responses

decreased locomotor activity ( J:155739 )

• decrease in Drd-1 agonist SKE 81291 induced locomotor and exploratory responses

nervous system

nervous system phenotype ( J:155739 )

N • no major impact on regulation of neuronal morphology and basal electrophysiological features of Drd2-expressing MSNs in the striatum

Genotype
MGI:5660864

cn2

• Allelic Composition: Nlgn3^tm4.1Sud/Y; Tg(Drd1-cre)EY262Gsat/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

behavior/neurological

enhanced learning ( J:214636 )

♂ • mice exhibit increased learning rate on the accelerating rotarod

hyperactivity ( J:214636 )

♂ • mice exhibit increased open-field activity

Genotype
MGI:5660866

cn3

• Allelic Composition: Nlgn3^tm1Sud/Y; Tg(Drd1-cre)EY262Gsat/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

behavior/neurological

enhanced learning ( J:214636 )

♂ • mice exhibit increased learning rate but similar initial coordination on the accelerating rotarod

increased stereotypic behavior ( J:214636 )

♂ • mice perform similarly to wild-type littermates on the first trial of an accelerating rotarod, however in the last several trials, mice exhibit enhanced performance, with increased time on the rotarod before falling off compared to wild-type mice, indicating enhanced formation of repetitive motor routine

Genotype
MGI:5563804

cn4

• Allelic Composition: Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans; Tg(Drd1-cre)EY262Gsat/0
• Genetic Background: involves: BALB/cJ * C57BL/6J * FVB/N

mortality/aging

premature death ( J:205260 )

• at about 5 months of age

behavior/neurological

hyperactivity ( J:205260 )

• juvenile

• administration of a MAP2K1 specific inhibitor SL327 normalizes locomotor activity

increased vertical activity ( J:205260 )

seizures ( J:205260 )

nervous system

seizures ( J:205260 )

increased dendritic spine number ( J:205260 )

• about a 20% increase in functional dendritic spines in striatal slices

abnormal action potential ( J:205260 )

• enhanced dendritic excitability in striatal slices

Genotype
MGI:4830459

cn5

• Allelic Composition: Ppp1r1b^tm5.1Pggd/Ppp1r1b^tm5.1Pggd; Tg(Drd1-cre)EY262Gsat/0; Tg(Drd1-EGFP)X60Gsat/0
• Genetic Background: involves: C57BL/6 * FVB/N * FVB/NTac

nervous system

reduced long-term potentiation ( J:163700 )

• loss of expression in striatopallidal and striatonigral neurons results in a reduced LTP at the corticostriatal synapses

behavior/neurological

impaired behavioral response to xenobiotic ( J:163700 )

• haloperidol-induced catalepsy is reduced

• L-DOPA-induced dyskinesia. is absent

impaired behavioral response to cocaine ( J:163700 )

decreased locomotor activity ( J:163700 )

• in an open-field test