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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Drd2-cre)ER44Gsat
transgene insertion ER44, GENSAT Project at Rockefeller University
MGI:3836635
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ehmt2tm1.1Tara/Ehmt2tm1.1Tara
Tg(Drd2-cre)ER44Gsat/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4418569
cn2
 		Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Drd2-cre)ER44Gsat/0 		involves: C57BL/6 * FVB/N MGI:5515337
cn3
 		Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd
Tg(Drd2-cre)ER44Gsat/0
Tg(Drd2-EGFP)S118Gsat/0 		involves: C57BL/6 * FVB/N * FVB/NTac MGI:4830460


Genotype
MGI:4418569
cn1
Allelic
Composition		 Ehmt2tm1.1Tara/Ehmt2tm1.1Tara
Tg(Drd2-cre)ER44Gsat/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt2tm1.1Tara mutation (0 available); any Ehmt2 mutation (57 available)
Tg(Drd2-cre)ER44Gsat mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron physiology ( J:155739 )
• small significant negative gain in excitability of medium spiny neurons

behavior/neurological
enhanced behavioral response to xenobiotic ( J:155739 )
• greater increase in locomotor and exploratory behaviors in response to caffeine, a repressor of Drd2.
induced hyperactivity ( J:155739 )
• greater increase in locomotor and exploratory behaviors in response by to caffeine, a repressor of Drd2




Genotype
MGI:5515337
cn2
Allelic
Composition		 Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Drd2-cre)ER44Gsat/0
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
Prkar2btm3Gsm mutation (0 available); any Prkar2b mutation (27 available)
Tg(Drd2-cre)ER44Gsat mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:196157 )
N
• hyperactivity phenotype is lost

adipose tissue

growth/size/body
decreased body weight ( J:196157 )
• low body weight
• lean body

homeostasis/metabolism
decreased circulating leptin level ( J:196157 )
• low serum leptin levels




Genotype
MGI:4830460
cn3
Allelic
Composition		 Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd
Tg(Drd2-cre)ER44Gsat/0
Tg(Drd2-EGFP)S118Gsat/0
Genetic
Background		 involves: C57BL/6 * FVB/N * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r1btm5.1Pggd mutation (0 available); any Ppp1r1b mutation (18 available)
Tg(Drd2-cre)ER44Gsat mutation (2 available)
Tg(Drd2-EGFP)S118Gsat mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
reduced long-term potentiation ( J:163700 )
• loss of expression in striatopallidal and striatonigral neurons results in a reduced LTP at the corticostriatal synapses

behavior/neurological
impaired behavioral response to xenobiotic ( J:163700 )
• haloperidol-induced catalepsy is strongly reduced
hyperactivity ( J:163700 )
• in an open-field test




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory