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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slamf7tm1Vei
targeted mutation 1, Andre Veillette
MGI:3836722
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slamf7tm1Vei/Slamf7tm1Vei involves: 129S1/Sv * 129X1/SvJ MGI:3836741


Genotype
MGI:3836741
hm1
Allelic
Composition		 Slamf7tm1Vei/Slamf7tm1Vei
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slamf7tm1Vei mutation (0 available); any Slamf7 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired natural killer cell mediated cytotoxicity ( J:145969 )
• mutant NK cells not only lack enhanced lysis of target cells expressing Slamf7 (CRACC) but also have impaired lysis of some Slamf7- target cells
• mice are less able to clear RMA-S lymphoma cells when injected into the peritoneal cavity

hematopoietic system
impaired natural killer cell mediated cytotoxicity ( J:145969 )
• mutant NK cells not only lack enhanced lysis of target cells expressing Slamf7 (CRACC) but also have impaired lysis of some Slamf7- target cells
• mice are less able to clear RMA-S lymphoma cells when injected into the peritoneal cavity




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory