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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cyp2j5tm1Dcz
targeted mutation 1, Darryl C Zeldin
MGI:3836754
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cyp2j5tm1Dcz/Cyp2j5tm1Dcz 129S/SvEv-Cyp2j5tm1Dcz MGI:3836755


Genotype
MGI:3836755
hm1
Allelic
Composition
Cyp2j5tm1Dcz/Cyp2j5tm1Dcz
Genetic
Background
129S/SvEv-Cyp2j5tm1Dcz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp2j5tm1Dcz mutation (0 available); any Cyp2j5 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• females but not males show a significant increase in systolic blood pressure compared to sex-matched controls
• difference in females is seen when mice are on a high or low salt diet
• estrogen supplementation reduces systolic blood pressures in females to normal levels
• vasoconstriction in response to angiotensin II and endothelin I is enhanced in arterioles from females but not in those from males
• for both males and females baseline arteriole diameters are similar to controls
• supplementation with estrogen attenuates arteriole responses to angiotensin II in females but not in wild -type controls

homeostasis/metabolism
• decrease in 17beta-estradiol levels in females compared to female littermate controls

renal/urinary system
N
• despite loss of expression in the kidneys, assays of gross kidney function (urine osmolality, serum creatinine, urine output) are normal
• increase in proximal tubular transport rates in females but not in males

reproductive system
• when females are continuously mated to wild-type males litter sizes are significantly smaller compared to crosses of wild-type females to wild-type males

muscle
• vasoconstriction in response to angiotensin II and endothelin I is enhanced in arterioles from females but not in those from males
• for both males and females baseline arteriole diameters are similar to controls
• supplementation with estrogen attenuates arteriole responses to angiotensin II in females but not in wild -type controls





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory