Phenotypes associated with this allele

• Allele Symbol: Mmp28^tm1Mani
• Allele Name: targeted mutation 1, Anne M Manicone
• Allele ID: MGI:3836773
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmp28^tm1Mani/Mmp28^tm1Mani	B6.129X1-Mmp28^tm1Mani	MGI:3836778

Genotype
MGI:3836778

hm1

• Allelic Composition: Mmp28^tm1Mani/Mmp28^tm1Mani
• Genetic Background: B6.129X1-Mmp28^tm1Mani

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage chemotaxis ( J:145912 )

• there is a 6-fold increase in the number of macrophages found in bronchoalveolar lavage fluid (BALF) 4 hours after aerosolized P. aeruginosa infection

• mutant bone marrow derived macrophages have increased rates of migration to BALF fluids isolated from infected mice

impaired neutrophil recruitment ( J:145912 )

• there is a significant decrease in the number of neutrophils found in bronchoalveolar lavage fluid 24 hours after aerosolized P. aeruginosa infection

abnormal cytokine secretion ( J:145912 )

• GM-CSF secretion is enhanced in the lungs 4 hours after aerosolized P. aeruginosa infection

abnormal chemokine secretion ( J:145912 )

• lung homogenates and bronchoalveolar lavage fluid (BALF) contain significantly less levels of the CXC chemokines KC and MIP-2 four hours after aerosolized P. aeruginosa infection

• there is also a slight decrease in MIP-3alpha levels in BALF after infection

increased interleukin-6 secretion ( J:145912 )

• IL-6 secretion is enhanced in the lungs 4 hours after aerosolized P. aeruginosa infection

increased tumor necrosis factor secretion ( J:145912 )

• TNF secretion is increased in the lungs 4 hours after aerosolized P. aeruginosa infection

decreased susceptibility to bacterial infection ( J:145912 )

• mice have enhanced clearance of bacteria in the lungs 4 hours after aerosolized P. aeruginosa infection

cellular

abnormal macrophage chemotaxis ( J:145912 )

• there is a 6-fold increase in the number of macrophages found in bronchoalveolar lavage fluid (BALF) 4 hours after aerosolized P. aeruginosa infection

• mutant bone marrow derived macrophages have increased rates of migration to BALF fluids isolated from infected mice

hematopoietic system

abnormal macrophage chemotaxis ( J:145912 )

• there is a 6-fold increase in the number of macrophages found in bronchoalveolar lavage fluid (BALF) 4 hours after aerosolized P. aeruginosa infection

• mutant bone marrow derived macrophages have increased rates of migration to BALF fluids isolated from infected mice

impaired neutrophil recruitment ( J:145912 )

• there is a significant decrease in the number of neutrophils found in bronchoalveolar lavage fluid 24 hours after aerosolized P. aeruginosa infection