Phenotypes associated with this allele

• Allele Symbol: Lyn^weeb
• Allele Name: WeeB
• Allele ID: MGI:3837125
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lyn^weeb/Lyn^weeb	C57BL/6-Lyn^weeb	MGI:3837133

Genotype
MGI:3837133

hm1

• Allelic Composition: Lyn^weeb/Lyn^weeb
• Genetic Background: C57BL/6-Lyn^weeb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell proliferation ( J:146161 )

• B cells from mice 7- to 11- weeks of age hyperproliferate in response to anti-IgM stimulation but not LPS

spleen hyperplasia ( J:146161 )

• spleens become enlarged with age with an accumulation of lymphoblast-like cells

decreased transitional stage B cell number ( J:146161 )

• reduced numbers of T1 and T2 B cells are found in the spleen

decreased mature B cell number ( J:146161 )

• peripheral B cell numbers are reduced more than half

decreased follicular B cell number ( J:146161 )

• reduced by about 4-fold in the spleen

decreased marginal zone B cell number ( J:146161 )

• reduced numbers in the spleen

disorganized spleen B cell follicle ( J:146161 )

• the B cell zones become disorganized in the spleen with age

increased IgM level ( J:146161 )

• mice have about 50% higher levels of IgM in the sera

increased anti-double stranded DNA antibody level ( J:146161 )

• serum levels of anti-dsDNA antibodies increase with age with high levels occurring by 10 months of age

liver inflammation ( J:146161 )

• IgG depositions occur in the liver of older mice though no associated pathology is observed

glomerulonephritis ( J:146161 )

• mice develop severe glomerulonephritis around 12- to 14- months of age

• disease includes enlarged glomeruli, glomerular, hypercellularity, lobularity and sclerosis, mesangial interposition in peripheral capillary loops, and strong IgG deposition in the glomeruli

liver/biliary system

liver inflammation ( J:146161 )

• IgG depositions occur in the liver of older mice though no associated pathology is observed

renal/urinary system

mesangial cell interposition ( J:146161 )

• mesangial interposition in peripheral capillary loops

glomerulonephritis ( J:146161 )

• mice develop severe glomerulonephritis around 12- to 14- months of age

• disease includes enlarged glomeruli, glomerular, hypercellularity, lobularity and sclerosis, mesangial interposition in peripheral capillary loops, and strong IgG deposition in the glomeruli

glomerulosclerosis ( J:146161 )

renal glomerulus hypertrophy ( J:146161 )

• enlarged glomeruli

hematopoietic system

increased B cell proliferation ( J:146161 )

• B cells from mice 7- to 11- weeks of age hyperproliferate in response to anti-IgM stimulation but not LPS

spleen hyperplasia ( J:146161 )

• spleens become enlarged with age with an accumulation of lymphoblast-like cells

decreased transitional stage B cell number ( J:146161 )

• reduced numbers of T1 and T2 B cells are found in the spleen

decreased mature B cell number ( J:146161 )

• peripheral B cell numbers are reduced more than half

decreased follicular B cell number ( J:146161 )

• reduced by about 4-fold in the spleen

decreased marginal zone B cell number ( J:146161 )

• reduced numbers in the spleen

disorganized spleen B cell follicle ( J:146161 )

• the B cell zones become disorganized in the spleen with age

increased IgM level ( J:146161 )

• mice have about 50% higher levels of IgM in the sera

growth/size/body

spleen hyperplasia ( J:146161 )

• spleens become enlarged with age with an accumulation of lymphoblast-like cells

cellular

mesangial cell interposition ( J:146161 )

• mesangial interposition in peripheral capillary loops

increased B cell proliferation ( J:146161 )

• B cells from mice 7- to 11- weeks of age hyperproliferate in response to anti-IgM stimulation but not LPS