All Phenotypes Mapk14<tm1Jda> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapk14^tm1Jda/Mapk14^tm1Jda	B6.Cg-Mapk14^tm1Jda	MGI:3837212
cx2	Mapk11^tm1Jda/Mapk11^tm1Jda Mapk14^tm1Jda/Mapk14^tm1Jda	involves: 129 * C57BL/6	MGI:4839286

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:146088 )

• following TCR stimulation, T cells exhibit delayed proliferation compared to in similarly treated wild-type cells

• however, T cell proliferation induced by PMA and ionomycin is normal

increased double-negative T cell number ( J:146088 )

• the number of DN4 cells is increased compared to in wild-type mice

• however, other DN thymocytes exhibit normal numbers

abnormal T-helper 1 physiology ( J:146088 )

• TCR stimulated Th1 function is impaired in mice polarized with soluble antigens from T gondii tachyzoites

• however, Th1 cell differentiation is normal

decreased interferon-alpha secretion ( J:146088 )

• in T cells stimulated with anti-CD3/CD28 antibodies

decreased interferon-gamma secretion ( J:146088 )

• T cells stimulated with anti-CD3/CD28 antibodies exhibit fewer cells producing IFN-gamma and reduced production levels compared to in similarly treated wild-type cells

• however, IFN-gamma production following stimulation with IL12 plus IL18 and PMA plus ionomycin is normal

• T cells polarized into Th1 cells by exposure to soluble antigens from T gondii tachyzoites exhibit reduced IFN-gamma production upon TCR stimulation compared in similarly treated wild-type cells

hematopoietic system

decreased T cell proliferation ( J:146088 )

• following TCR stimulation, T cells exhibit delayed proliferation compared to in similarly treated wild-type cells

• however, T cell proliferation induced by PMA and ionomycin is normal

increased double-negative T cell number ( J:146088 )

• the number of DN4 cells is increased compared to in wild-type mice

• however, other DN thymocytes exhibit normal numbers

abnormal T-helper 1 physiology ( J:146088 )

• TCR stimulated Th1 function is impaired in mice polarized with soluble antigens from T gondii tachyzoites

• however, Th1 cell differentiation is normal

cellular

decreased T cell proliferation ( J:146088 )

• following TCR stimulation, T cells exhibit delayed proliferation compared to in similarly treated wild-type cells

• however, T cell proliferation induced by PMA and ionomycin is normal

Allelic Composition	Mapk11^tm1Jda/Mapk11^tm1Jda Mapk14^tm1Jda/Mapk14^tm1Jda
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk11^tm1Jda mutation (1 available); any Mapk11 mutation (35 available)
Mapk14^tm1Jda mutation (1 available); any Mapk14 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:165966 )

abnormal T-helper 1 cell differentiation ( J:165966 )

• Th1 polarization is impaired compared to in single homozygote

abnormal T-helper 2 cell differentiation ( J:165966 )

• Th2 polarization is enhanced compared to in single homozygote

abnormal T-helper 17 cell differentiation ( J:165966 )

• Th17 polarization is impaired compared to in single homozygote

decreased interferon-gamma secretion ( J:165966 )

• in response to TCR-stimulation

increased interleukin-10 secretion ( J:165966 )

decreased tumor necrosis factor secretion ( J:165966 )

• in response to TCR-stimulation

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:165966 )

• diminished onset and severity

decreased susceptibility to induced arthritis ( J:165966 )

• diminished onset and severity

skeleton

decreased susceptibility to induced arthritis ( J:165966 )

• diminished onset and severity

hematopoietic system

decreased T cell proliferation ( J:165966 )

abnormal T-helper 1 cell differentiation ( J:165966 )

• Th1 polarization is impaired compared to in single homozygote

abnormal T-helper 2 cell differentiation ( J:165966 )

• Th2 polarization is enhanced compared to in single homozygote

abnormal T-helper 17 cell differentiation ( J:165966 )

• Th17 polarization is impaired compared to in single homozygote

cellular

decreased T cell proliferation ( J:165966 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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