About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mthfd1Gt(XB175)Byg
gene trap XB175, BayGenomics
MGI:3837220
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mthfd1Gt(XB175)Byg/Mthfd1Gt(XB175)Byg B6.129P2-Mthfd1Gt(XB175)Byg MGI:3837226
ht2
Mthfd1Gt(XB175)Byg/Mthfd1+ involves: 129P2/OlaHsd * C57BL/6 MGI:3837228


Genotype
MGI:3837226
hm1
Allelic
Composition
Mthfd1Gt(XB175)Byg/Mthfd1Gt(XB175)Byg
Genetic
Background
B6.129P2-Mthfd1Gt(XB175)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mthfd1Gt(XB175)Byg mutation (0 available); any Mthfd1 mutation (79 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3837228
ht2
Allelic
Composition
Mthfd1Gt(XB175)Byg/Mthfd1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mthfd1Gt(XB175)Byg mutation (0 available); any Mthfd1 mutation (79 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice fed a folate and choline deficient diet (FCD) exhibit a 40% greater reduction in the levels of S-adenosylmethionine in the liver compared to similarly treated wild-type mice
• however, S-adenosylmethionine levels in the colon are normal and normally reduced in mice fed an FCD diet
• when fed a standard diet, mice exhibit decreased concentrations of cystathionine compared to in wild-type mice
• whether fed a standard or FCD diet, mice exhibit higher levels of alpha-aminobutyric acid compared to in similarly treated wild-type mice without exhibiting an increase in levels when fed the FCD unlike wild-type mice
• C1THF synthase is decreased 50% in the kidney, liver, colon, and brain compared to in wild-type mice
• when fed a folate and choline deficient diet, mice less of an increase in the uracil content of DNA in the colon compared to similarly treated wild-type mice

growth/size/body
• at weaning and the following two weeks, mice exhibit increased body weight compared to wild-type mice regardless of diet
• however, three to five weeks after weaning mice weigh as much as wild-type mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory