Phenotypes associated with this allele

• Allele Symbol: Dhx58^tm1Gnb
• Allele Name: targeted mutation 1, Glen N Barber
• Allele ID: MGI:3837303
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dhx58^tm1Gnb/Dhx58^tm1Gnb	involves: 129P2/OlaHsd * C57BL/6J	MGI:3837330

Genotype
MGI:3837330

hm1

• Allelic Composition: Dhx58^tm1Gnb/Dhx58^tm1Gnb
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:146113 )

• mice exhibit decreased mortality associated with vesicular stomatitis virus (VSV) infection compared to similarly treated wild-type mice

increased susceptibility to induced morbidity/mortality ( J:146113 )

• encephalomyocarditis virus (EMCV)-infected mice exhibit increased lethality compared to similarly treated wild-type mice

immune system

increased circulating interferon-gamma level ( J:146113 )

• in VSV-infected mice

increased circulating interleukin-12 level ( J:146113 )

• in VSV-infected mice

abnormal interferon secretion ( J:146113 )

• encephalomyocarditis virus (EMCV)-infected macrophages or bone marrow-derived dendritic cells exhibit defective type I IFN production unlike similarly treated wild-type cells

• however, EMCV-infected mouse embryonic fibroblasts exhibit normal type I IFN production

decreased interferon-alpha secretion ( J:146113 )

• in the brains of VSV-infected mice

increased interferon-alpha secretion ( J:146113 )

• polyI:C-stimulated mouse embryonic fibroblasts produce several-fold more IFN-alpha compared to similarly treated wild-type cells

decreased interferon-beta secretion ( J:146113 )

• in the brains of VSV-infected mice

increased interferon-beta secretion ( J:146113 )

• polyI:C-stimulated mouse embryonic fibroblasts (MEFs) produce several-fold more IFN-beta compared to similarly treated wild-type cells

• MEFs exposed to vesicular stomatitis virus (VSV) exhibit increased IFN-beta production compared to similarly treated wild-type cells

abnormal susceptibility to Riboviria infection ( J:146113 )

• mouse embryonic fibroblasts (MEFs) exposed to vesicular stomatitis virus (VSV) exhibit increased IFN-beta production compared to similarly treated wild-type cells

• replication of a defective M protein VSV in MEFs is lower than in wild-type cells

• however, viral titers in VSV-infected MEFs are normal

increased susceptibility to Picornaviridae infection ( J:146113 )

• encephalomyocarditis virus (EMCV)-infected macrophages or bone marrow-derived dendritic cells exhibit defective type I IFN production unlike similarly treated wild-type cells

• EMCV-infected mice exhibit increased lethality compared to similarly treated wild-type mice

• however, EMCV-infected mouse embryonic fibroblasts exhibit normal type I IFN production

decreased susceptibility to Riboviria infection ( J:146113 )

• mice exhibit decreased mortality associated with vesicular stomatitis virus (VSV) infection compared to similarly treated wild-type mice

• VSV-infected mice exhibit increased serum IL12 and IFN-gamma levels, decreased IFN-alpha and beta production in the brain, and lower viral titers than in similarly treated wild-type mice

homeostasis/metabolism

increased circulating interferon-gamma level ( J:146113 )

• in VSV-infected mice

increased circulating interleukin-12 level ( J:146113 )

• in VSV-infected mice