All Phenotypes Mcl1<tm1Yen> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcl1^tm1Yen/Mcl1^tm1Yen	B6.129-Mcl1^tm1Yen	MGI:3837391
cx2	Mcl1^tm1Yen/Mcl1^tm1Yen Tg(TcraTcrb)425Cbn/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3837392
cx3	Mcl1^tm1Yen/Mcl1^tm1Yen Tg(TcraH-Y,TcrbH-Y)71Vbo/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:3837393

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased double-negative T cell number ( J:146246 )

• absolute numbers for both DN1 and DN2 populations are slightly but significantly reduced in the thymus

abnormal double-positive T cell morphology ( J:146246 )

• the proportion of double positive thymocytes undergoing positive selection (i.e. expressing high levels of activation markers) is reduced

• double-positive thymocytes have higher rates of apoptosis when cultured without growth factors or when stimulated in vivo by anti-CD3 treatment

decreased CD8-positive, alpha-beta T cell number ( J:146246 )

• mice have a 35% reduction in CD8⁺ T cells in the spleen and lymph nodes

decreased single-positive T cell number ( J:146246 )

• single-positive CD4 and CD8 T cells in the thymus have slight reduction in numbers within the thymus

abnormal CD8-positive, alpha-beta T cell physiology ( J:146246 )

• 50% more CD8⁺ T cells are apoptotic than controls when cultured 36 hours without growth factors

• the in vivo viability of CD8⁺ T cells is also 50% of controls 5 days after transfer to immunocompetent hosts

hematopoietic system

decreased double-negative T cell number ( J:146246 )

• absolute numbers for both DN1 and DN2 populations are slightly but significantly reduced in the thymus

abnormal double-positive T cell morphology ( J:146246 )

• the proportion of double positive thymocytes undergoing positive selection (i.e. expressing high levels of activation markers) is reduced

• double-positive thymocytes have higher rates of apoptosis when cultured without growth factors or when stimulated in vivo by anti-CD3 treatment

decreased CD8-positive, alpha-beta T cell number ( J:146246 )

• mice have a 35% reduction in CD8⁺ T cells in the spleen and lymph nodes

decreased single-positive T cell number ( J:146246 )

• single-positive CD4 and CD8 T cells in the thymus have slight reduction in numbers within the thymus

abnormal CD8-positive, alpha-beta T cell physiology ( J:146246 )

• 50% more CD8⁺ T cells are apoptotic than controls when cultured 36 hours without growth factors

• the in vivo viability of CD8⁺ T cells is also 50% of controls 5 days after transfer to immunocompetent hosts

Allelic Composition	Mcl1^tm1Yen/Mcl1^tm1Yen Tg(TcraTcrb)425Cbn/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1^tm1Yen mutation (0 available); any Mcl1 mutation (35 available)
Tg(TcraTcrb)425Cbn mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal double-positive T cell morphology ( J:146246 )

• mice have decreased numbers of double positive thymocytes expressing the transgenic TCR

decreased CD4-positive, alpha-beta T cell number ( J:146246 )

• mice have decreased frequency and numbers of transgenic CD4⁺ T cells in the thymus and in the periphery

hematopoietic system

abnormal double-positive T cell morphology ( J:146246 )

• mice have decreased numbers of double positive thymocytes expressing the transgenic TCR

decreased CD4-positive, alpha-beta T cell number ( J:146246 )

• mice have decreased frequency and numbers of transgenic CD4⁺ T cells in the thymus and in the periphery

Allelic Composition	Mcl1^tm1Yen/Mcl1^tm1Yen Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1^tm1Yen mutation (0 available); any Mcl1 mutation (35 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal double-positive T cell morphology ( J:146246 )

• mice have decreased numbers of double positive thymocytes expressing the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:146246 )

• female mice have decreased frequency and numbers of transgenic CD8⁺ T cells in the thymus and in the periphery

hematopoietic system

abnormal double-positive T cell morphology ( J:146246 )

• mice have decreased numbers of double positive thymocytes expressing the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:146246 )

• female mice have decreased frequency and numbers of transgenic CD8⁺ T cells in the thymus and in the periphery

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