About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrp5tm3(Lrp5*)Kry
targeted mutation 3, Gerard Karsenty
MGI:3837395
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry
Tg(Vil1-cre)20Syr/0 		involves: C57BL/6 * DBA/2 MGI:3837405
cn2
 		Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry
Tg(Col1a1-cre)1Kry/0 		involves: FVB MGI:3837406


Genotype
MGI:3837405
cn1
Allelic
Composition		 Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry
Tg(Vil1-cre)20Syr/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm3(Lrp5*)Kry mutation (0 available); any Lrp5 mutation (82 available)
Tg(Vil1-cre)20Syr mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased serotonin level ( J:146078 )
• decreased circulating serotonin levels

skeleton
increased bone ossification ( J:146078 )
• increased bone formation




Genotype
MGI:3837406
cn2
Allelic
Composition		 Lrp5tm3(Lrp5*)Kry/Lrp5tm3(Lrp5*)Kry
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm3(Lrp5*)Kry mutation (0 available); any Lrp5 mutation (82 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:146078 )
N
• unlike mice with conditional expression in the gut, mice with conditional expression in osteoblasts have normal circulating serotonin levels

skeleton
skeleton phenotype ( J:146078 )
N
• unlike mice with conditional expression in the gut, mice with conditional expression in osteoblasts have normal bone mass and bone formation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory