Phenotypes associated with this allele

• Allele Symbol: Lrp5^{tm3(Lrp5*)Kry}
• Allele Name: targeted mutation 3, Gerard Karsenty
• Allele ID: MGI:3837395
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lrp5^tm3(Lrp5*)Kry/Lrp5^tm3(Lrp5*)Kry Tg(Vil1-cre)20Syr/0	involves: C57BL/6 * DBA/2	MGI:3837405
cn2	Lrp5^tm3(Lrp5*)Kry/Lrp5^tm3(Lrp5*)Kry Tg(Col1a1-cre)1Kry/0	involves: FVB	MGI:3837406

Genotype
MGI:3837405

cn1

• Allelic Composition: Lrp5^{tm3(Lrp5*)Kry}/Lrp5^{tm3(Lrp5*)Kry}; Tg(Vil1-cre)20Syr/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased serotonin level ( J:146078 )

• decreased circulating serotonin levels

skeleton

increased bone mass ( J:146078 )

increased bone ossification ( J:146078 )

• increased bone formation

Genotype
MGI:3837406

cn2

• Allelic Composition: Lrp5^{tm3(Lrp5*)Kry}/Lrp5^{tm3(Lrp5*)Kry}; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: FVB

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:146078 )

N • unlike mice with conditional expression in the gut, mice with conditional expression in osteoblasts have normal circulating serotonin levels

skeleton

skeleton phenotype ( J:146078 )

N • unlike mice with conditional expression in the gut, mice with conditional expression in osteoblasts have normal bone mass and bone formation