Analysis Tools
immune system
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• an acidic extracellular environment has less inhibition on LPS-induced TNF secretion by macrophages than in controls
• at pH 6.4, TNF secretion is reduced by 40% compared to a 80% reduction in wild-type controls
• similar results occur when TNF secretion is induced by polyI:C agonist
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• in microglia cells derived from homozygous mice, extracellular acidic pH inhibits lipopolysaccharide -induced IL-1beta production
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hematopoietic system
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• an acidic extracellular environment has less inhibition on LPS-induced TNF secretion by macrophages than in controls
• at pH 6.4, TNF secretion is reduced by 40% compared to a 80% reduction in wild-type controls
• similar results occur when TNF secretion is induced by polyI:C agonist
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skeleton
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• the BMC/TV values are significantly reduced by ovariectomy
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• the ovariectomized mutant mice display a greater reduction in the femoral BV/TV than the ovariectomized control mice
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