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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Tek-icre/ERT2)1Soff
transgene insertion 1, Stefan Offermanns
MGI:3837451
Summary 5 genotypes


Genotype
MGI:5800455
cn1
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Tek-icre/ERT2)1Soff/0
Genetic
Background		 B6N.Cg-Gna11tm1Soff Gnaqtm2Soff Tg(Tek-icre/ERT2)1Soff
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm2Soff mutation (0 available); any Gnaq mutation (24 available)
Tg(Tek-icre/ERT2)1Soff mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased susceptibility to hypertension ( J:224523 )
• in response to tamoxifen
decreased vasodilation ( J:224523 )
• almost complete lost of dilation in response to flow
• inhibited acethylcholine-induced vasodilation
• however, vasodilation in response to sodium nitroprusside and vasoconstriction in response to phenylephrine are normal
abnormal vascular wound healing ( J:224523 )
• in response to ligation of the external carotid artery, mice exhibit a strong reduction in neointima formation compared with control mice
• however, there is no change in the diameter of the common carotid artery

homeostasis/metabolism
abnormal vascular wound healing ( J:224523 )
• in response to ligation of the external carotid artery, mice exhibit a strong reduction in neointima formation compared with control mice
• however, there is no change in the diameter of the common carotid artery
decreased nitrate level ( J:224523 )
• decreased in the plasma of tamoxifen-treated mice

muscle
decreased vasodilation ( J:224523 )
• almost complete lost of dilation in response to flow
• inhibited acethylcholine-induced vasodilation
• however, vasodilation in response to sodium nitroprusside and vasoconstriction in response to phenylephrine are normal




Genotype
MGI:5800452
cn2
Allelic
Composition		 P2ry2tm1c(EUCOMM)Hmgu/P2ry2tm1c(EUCOMM)Hmgu
Tg(Tek-icre/ERT2)1Soff/0
Genetic
Background		 B6N.Cg-P2ry2tm1c(EUCOMM)Hmgu Tg(Tek-icre/ERT2)1Soff
Cell Lines HEPD0557_7_B07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2ry2tm1c(EUCOMM)Hmgu mutation (0 available); any P2ry2 mutation (18 available)
Tg(Tek-icre/ERT2)1Soff mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased vasodilation ( J:224523 )
• almost complete lost of dilation in response to flow
• however, vasodilation in response to sodium nitroprusside and vasoconstriction in response to phenylephrine are normal

muscle
decreased vasodilation ( J:224523 )
• almost complete lost of dilation in response to flow
• however, vasodilation in response to sodium nitroprusside and vasoconstriction in response to phenylephrine are normal




Genotype
MGI:3837460
cn3
Allelic
Composition		 Gna12tm1Citb/Gna12tm1Citb
Gna13tm2.1Soff/Gna13tm2.1Soff
Tg(Tek-icre/ERT2)1Soff/?
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation (0 available); any Gna12 mutation (23 available)
Gna13tm2.1Soff mutation (0 available); any Gna13 mutation (12 available)
Tg(Tek-icre/ERT2)1Soff mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:146132 )
N
• tamoxifen-treated mice respond similar to wild-type controls in experiments testing response to anaphylactic shock




Genotype
MGI:3837458
cn4
Allelic
Composition		 Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Tek-icre/ERT2)1Soff/?
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11tm1Soff mutation (0 available); any Gna11 mutation (25 available)
Gnaqtm2Soff mutation (0 available); any Gnaq mutation (24 available)
Tg(Tek-icre/ERT2)1Soff mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased vascular permeability ( J:146132 )
• in mice with induction of cre recombinase, basal permeability is lower than controls
• vascular permeability does not increase above basal levels in response to histamine, IgE, platelet-activating factor (PAF), lysophosphatidic acid (LPA), or F2r-activating peptide
• mice are resistant to death resulting from PAF-induced shock

immune system
immune system phenotype ( J:146132 )
N
• while resistant to shock induced by IgE or vasoactive substances, mice are not resistant to shock induced by LPS
decreased susceptibility to type I hypersensitivity reaction ( J:146132 )
• tamoxifen treated mice are resistant to IgE-induced anaphylactic shock
• in an anti-DNP model, mice only have transient drops in systolic blood pressure compared to the sustained (>90 min) drops that occur in controls
• in an anti-BSA model, all mice survive anaphylactic challenge with only moderate decreases in body temperature compared to controls that suffer from severe hypothermia and death within 20 min of challenge




Genotype
MGI:5780104
cn5
Allelic
Composition		 Mapre3tm1c(EUCOMM)Wtsi/Mapre3tm1c(EUCOMM)Wtsi
Tg(Tek-icre/ERT2)1Soff/0
Genetic
Background		 involves: C57BL/6N * FVB/N
Cell Lines EPD0144_4_G05
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapre3tm1c(EUCOMM)Wtsi mutation (0 available); any Mapre3 mutation (17 available)
Tg(Tek-icre/ERT2)1Soff mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal vascular permeability ( J:224855 )
• after infusion with a peptide agonist of PAR-1 (F2r), lung vasculature fails to exhibit hyper-permeability unlike in wild-type mice
• however, untreated mice exhibit normal adult microvasculature in the lungs




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory