Phenotypes associated with this allele

• Allele Symbol: Trim32^{Gt(BGA355)Byg}
• Allele Name: gene trap BGA355, BayGenomics
• Allele ID: MGI:3837468
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim32^Gt(BGA355)Byg/Trim32^Gt(BGA355)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3837478

Genotype
MGI:3837478

hm1

• Allelic Composition: Trim32^{Gt(BGA355)Byg}/Trim32^{Gt(BGA355)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced fertility ( J:146155 )

• mice seem to produce litters less frequently than wild-type mice

decreased litter size ( J:146155 )

• mice seem to produce smaller litters than wild-type mice

muscle

muscle phenotype ( J:146155 )

N • despite abnormal skeletal muscle fiber morphology, mice do not exhibit regenerating fibers or denervation

abnormal skeletal muscle fiber morphology ( J:146155 )

decreased skeletal muscle fiber diameter ( J:146155 )

• skeletal muscle fibers are smaller in diameter

increased variability of skeletal muscle fiber size ( J:146155 )

• skeletal muscle fibers are more varied in diameter

centrally nucleated skeletal muscle fibers ( J:146155 )

• skeletal muscle fibers have centrally located nuclei

decreased muscle weight ( J:146155 )

abnormal skeletal muscle fiber type ratio ( J:146155 )

• mutant skeletal muscles exhibit a decrease in fast and an increase in slow myosin heavy chain isoform expression

myopathy ( J:146155 )

• skeletal muscle fibers exhibit sarcotubular myopathy

nervous system

abnormal axon morphology ( J:146155 )

• myelinated axons in the L4 ventral roots exhibit decreased diameter compared to in wild-type mice

• however, the number of axons is normal

behavior/neurological

impaired coordination ( J:146155 )

• on a wire hang test, mice exhibit reduced latency to fall compared to wild-type mice

decreased grip strength ( J:146155 )

• grip strength is reduced 17% compared to in wild-type mice

growth/size/body

increased body weight ( J:146155 )

• at 8 weeks and at later ages, male mice are 10% heavier than wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive limb-girdle muscular dystrophy type 2H		DOID:0110282	OMIM:254110	J:146155