About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pink1tm1Zhzh
targeted mutation 1, Zhuohua Zhang
MGI:3837552
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Pink1tm1Zhzh/Pink1tm1Zhzh
Slc6a3tm4.1(tTA)Xz/?
Tg(tetO-SNCA*A53T)E2Cai/? 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 MGI:5619815


Genotype
MGI:5619815
cx1
Allelic
Composition		 Pink1tm1Zhzh/Pink1tm1Zhzh
Slc6a3tm4.1(tTA)Xz/?
Tg(tetO-SNCA*A53T)E2Cai/?
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1tm1Zhzh mutation (0 available); any Pink1 mutation (43 available)
Slc6a3tm4.1(tTA)Xz mutation (1 available); any Slc6a3 mutation (66 available)
Tg(tetO-SNCA*A53T)E2Cai mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitochondrial morphology ( J:218892 )
• 51% reduction of mitochondrial mass at 3 weeks of age

nervous system
neuronal cytoplasmic inclusions ( J:218892 )
• "mitochondrial inclusions are observed in in dopaminergic neurons beginning at 3 weeks of age
• inclusions average 4.2 um in diameter and are labeled by mitochondrial markers (COX1, SOD2)
• number of inclusions is approximately 1.4 inclusions per dopaminergic neuron




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory