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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pink1tm1Zhzh
targeted mutation 1, Zhuohua Zhang
MGI:3837552
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Pink1tm1Zhzh/Pink1tm1Zhzh
Slc6a3tm4.1(tTA)Xz/?
Tg(tetO-SNCA*A53T)E2Cai/? 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 MGI:5619815


Genotype
MGI:5619815
cx1
Allelic
Composition		 Pink1tm1Zhzh/Pink1tm1Zhzh
Slc6a3tm4.1(tTA)Xz/?
Tg(tetO-SNCA*A53T)E2Cai/?
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1tm1Zhzh mutation (0 available); any Pink1 mutation (43 available)
Slc6a3tm4.1(tTA)Xz mutation (1 available); any Slc6a3 mutation (66 available)
Tg(tetO-SNCA*A53T)E2Cai mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitochondrial morphology ( J:218892 )
• 51% reduction of mitochondrial mass at 3 weeks of age

nervous system
neuronal cytoplasmic inclusions ( J:218892 )
• "mitochondrial inclusions are observed in in dopaminergic neurons beginning at 3 weeks of age
• inclusions average 4.2 um in diameter and are labeled by mitochondrial markers (COX1, SOD2)
• number of inclusions is approximately 1.4 inclusions per dopaminergic neuron




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory