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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Pvalb-cre)1Tama
transgene insertion 1, Nobuaki Tamamaki
MGI:3837553
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Scn1atm2.1Kzy/Scn1a+
Tg(Pvalb-cre)1Tama/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA MGI:5523888
cn2
 		Scn1atm2.1Kzy/Scn1atm2.1Kzy
Tg(Pvalb-cre)1Tama/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA MGI:5523889
cx3
 		Tg(CAG-mRFP,-GFP)1Tama/?
Tg(Pvalb-cre)1Tama/? 		involves: C57BL/6 * DBA MGI:3837561


Genotype
MGI:5523888
cn1
Allelic
Composition		 Scn1atm2.1Kzy/Scn1a+
Tg(Pvalb-cre)1Tama/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn1atm2.1Kzy mutation (1 available); any Scn1a mutation (114 available)
Tg(Pvalb-cre)1Tama mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
convulsive seizures ( J:202863 )
• some mice develop recurrent seizures after P16

mortality/aging
postnatal lethality ( J:202863 )
• some mice develop recurrent seizures after P16 and experience sporadic sudden death

nervous system
convulsive seizures ( J:202863 )
• some mice develop recurrent seizures after P16

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Dravet syndrome DOID:0080422 OMIM:607208
 J:202863




Genotype
MGI:5523889
cn2
Allelic
Composition		 Scn1atm2.1Kzy/Scn1atm2.1Kzy
Tg(Pvalb-cre)1Tama/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn1atm2.1Kzy mutation (1 available); any Scn1a mutation (114 available)
Tg(Pvalb-cre)1Tama mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:202863 )
• all animals die before P30

behavior/neurological
ataxia ( J:202863 )
• develops around P14
convulsive seizures ( J:202863 )
• mice are physically normal for first week postnatal, but around P10 develop spontaneous generalized convulsive seizures

nervous system
convulsive seizures ( J:202863 )
• mice are physically normal for first week postnatal, but around P10 develop spontaneous generalized convulsive seizures

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Dravet syndrome DOID:0080422 OMIM:607208
 J:202863




Genotype
MGI:3837561
cx3
Allelic
Composition		 Tg(CAG-mRFP,-GFP)1Tama/?
Tg(Pvalb-cre)1Tama/?
Genetic
Background		 involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory