Phenotypes associated with this allele

• Allele Symbol: Tg(Pvalb-cre)1Tama
• Allele Name: transgene insertion 1, Nobuaki Tamamaki
• Allele ID: MGI:3837553
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Scn1a^tm2.1Kzy/Scn1a^+ Tg(Pvalb-cre)1Tama/0	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:5523888
cn2	Scn1a^tm2.1Kzy/Scn1a^tm2.1Kzy Tg(Pvalb-cre)1Tama/0	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:5523889
cx3	Tg(CAG-mRFP,-GFP)1Tama/? Tg(Pvalb-cre)1Tama/?	involves: C57BL/6 * DBA	MGI:3837561

Genotype
MGI:5523888

cn1

• Allelic Composition: Scn1a^tm2.1Kzy/Scn1a⁺; Tg(Pvalb-cre)1Tama/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

convulsive seizures ( J:202863 )

• some mice develop recurrent seizures after P16

mortality/aging

postnatal lethality ( J:202863 )

• some mice develop recurrent seizures after P16 and experience sporadic sudden death

nervous system

convulsive seizures ( J:202863 )

• some mice develop recurrent seizures after P16

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Dravet syndrome		DOID:0080422	OMIM:607208	J:202863

Genotype
MGI:5523889

cn2

• Allelic Composition: Scn1a^tm2.1Kzy/Scn1a^tm2.1Kzy; Tg(Pvalb-cre)1Tama/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

mortality/aging

premature death ( J:202863 )

• all animals die before P30

behavior/neurological

ataxia ( J:202863 )

• develops around P14

convulsive seizures ( J:202863 )

• mice are physically normal for first week postnatal, but around P10 develop spontaneous generalized convulsive seizures

nervous system

convulsive seizures ( J:202863 )

• mice are physically normal for first week postnatal, but around P10 develop spontaneous generalized convulsive seizures

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Dravet syndrome		DOID:0080422	OMIM:607208	J:202863

Genotype
MGI:3837561

cx3

• Allelic Composition: Tg(CAG-mRFP,-GFP)1Tama/?; Tg(Pvalb-cre)1Tama/?
• Genetic Background: involves: C57BL/6 * DBA

normal phenotype

no abnormal phenotype detected ( J:146140 )