All Phenotypes Eef1a1<tm1(Kras*)Arge> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Eef1a1^{tm1(Kras*)Arge}
targeted mutation 1, Argiris Efstratiadis
MGI:3837679

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv	MGI:3837707
cn2	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Igf1r^tm2Arge/Igf1r⁺ Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv	MGI:3837708
cn3	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Igf1r^tm2Arge/Igf1r^tm2Arge Wap^tm1(cre)Arge/Wap⁺	involves: 129S1/Sv	MGI:3837711
cn4	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Tg(Hsp70-1-cre)1Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3837706

Allelic Composition	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1^{tm1(Kras*)Arge} mutation (0 available); any Eef1a1 mutation (60 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Histology and immunophenotyping of mammary carcinomas in Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Wap^tm1(cre)Arge/Wap⁺ mice

mortality/aging

decreased tumor-free survival time ( J:146290 )

• median tumor-free survival of lactating female mice is 9 days from the first parturition

neoplasm

increased mammary gland tumor incidence ( J:146290 )

• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice

• median tumor-free survival of lactating female mice is 9 days from the first parturition

• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas

• however, treatment with picropodophyllin decreases tumor mass

increased mammary adenocarcinoma incidence ( J:146290 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:146290 )

• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice

• median tumor-free survival of lactating female mice is 9 days from the first parturition

• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas

• however, treatment with picropodophyllin decreases tumor mass

increased mammary adenocarcinoma incidence ( J:146290 )

integument

increased mammary gland tumor incidence ( J:146290 )

• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice

• median tumor-free survival of lactating female mice is 9 days from the first parturition

• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas

• however, treatment with picropodophyllin decreases tumor mass

increased mammary adenocarcinoma incidence ( J:146290 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:146290

Allelic Composition	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Igf1r^tm2Arge/Igf1r⁺ Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1^{tm1(Kras*)Arge} mutation (0 available); any Eef1a1 mutation (60 available)
Igf1r^tm2Arge mutation (1 available); any Igf1r mutation (88 available)
Wap^tm1(cre)Arge mutation (0 available); any Wap mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:146290 )

• median tumor free survival of lactating females is 43 days from the first parturition

neoplasm

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 43 days from the first parturition

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 43 days from the first parturition

integument

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 43 days from the first parturition

Allelic Composition	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Igf1r^tm2Arge/Igf1r^tm2Arge Wap^tm1(cre)Arge/Wap⁺
Genetic Background	involves: 129S1/Sv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:146290 )

• median tumor free survival of lactating females is 101 days from the first parturition

neoplasm

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 101 days from the first parturition

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 101 days from the first parturition

integument

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 101 days from the first parturition

Allelic Composition	Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129S1/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1^{tm1(Kras*)Arge} mutation (0 available); any Eef1a1 mutation (60 available)
Tg(Hsp70-1-cre)1Arge mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality ( J:146290 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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