Phenotypes associated with this allele

• Allele Symbol: Camk2d^tm1.2Eno
• Allele Name: targeted mutation 1.2, Eric N Olson
• Allele ID: MGI:3837728
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camk2d^tm1.2Eno/Camk2d^tm1.2Eno	involves: 129S/SvEvBrd * C57BL/6 * CD-1 * SJL	MGI:3837732

Genotype
MGI:3837732

hm1

• Allelic Composition: Camk2d^tm1.2Eno/Camk2d^tm1.2Eno
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Diminished cardiac hypertrophy of Camk2d^tm1.2Eno/Camk2d^tm1.2Eno mice after thoracic aortic constriction

cardiovascular system

decreased response of heart to induced stress ( J:146285 )

• following thoracic aortic constriction (TAC), mice exhibit a 12% increase in heart weight to body weight compared to a 52% increase observed in similarly treated wild-type mice

• TAC-treated mice exhibit minimal increase in ventricular wall thickness with no fibrosis unlike similarly treated wild-type mice

• mice fail to exhibit an increase in cardiomyocyte size following TAC unlike wild-type mice

• TAC-treated wild-type mice exhibit less hypertrophy of cardiomyocytes compared to in similarly treated wild-type mice

• however, calcium ion handling inc cardiomyocytes is normal

homeostasis/metabolism

decreased response of heart to induced stress ( J:146285 )

• following thoracic aortic constriction (TAC), mice exhibit a 12% increase in heart weight to body weight compared to a 52% increase observed in similarly treated wild-type mice

• TAC-treated mice exhibit minimal increase in ventricular wall thickness with no fibrosis unlike similarly treated wild-type mice

• mice fail to exhibit an increase in cardiomyocyte size following TAC unlike wild-type mice

• TAC-treated wild-type mice exhibit less hypertrophy of cardiomyocytes compared to in similarly treated wild-type mice

• however, calcium ion handling inc cardiomyocytes is normal