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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tslptm1.1Pcn
targeted mutation 1.1, Pierre Chambon
MGI:3837749
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tslptm1.1Pcn/Tslptm1.1Pcn
Tg(KRT14-cre)1Ipc/0
involves: 129 * C57BL/6 * SJL MGI:3837766
cn2
Tslptm1.1Pcn/Tslptm1.1Pcn
Tg(KRT14-cre/ERT2)1Ipc/0
involves: 129 * C57BL/6 * SJL MGI:3837768


Genotype
MGI:3837766
cn1
Allelic
Composition
Tslptm1.1Pcn/Tslptm1.1Pcn
Tg(KRT14-cre)1Ipc/0
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)1Ipc mutation (0 available)
Tslptm1.1Pcn mutation (0 available); any Tslp mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• when treated with MC903 mice develop dry and scaly ears unlike similarly treated mice that develop red or inflamed lesions
• MC903-treated ears exhibit some the epidermal hyperplasia but not the heavy dermal cell infiltrate observed as in similarly treated wild-type mice
• at day 16 following application of MC903, mice exhibit a lesser increase in IgE levels compared to in similarly treated wild-type mice
• MC903-treated mice fail to exhibit an increase in eosinophil and lymphocyte counts compared to in similarly treated wild-type mice

immune system
• MC903-treated mice fail to exhibit an increase in eosinophil and lymphocyte counts compared to in similarly treated wild-type mice
• MC903-treated mice fail to exhibit an increase in eosinophil and lymphocyte counts compared to in similarly treated wild-type mice
• compared to in wild-type mice at day 16 following application of MC903

hematopoietic system
• MC903-treated mice fail to exhibit an increase in eosinophil and lymphocyte counts compared to in similarly treated wild-type mice
• MC903-treated mice fail to exhibit an increase in eosinophil and lymphocyte counts compared to in similarly treated wild-type mice
• compared to in wild-type mice at day 16 following application of MC903




Genotype
MGI:3837768
cn2
Allelic
Composition
Tslptm1.1Pcn/Tslptm1.1Pcn
Tg(KRT14-cre/ERT2)1Ipc/0
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre/ERT2)1Ipc mutation (1 available)
Tslptm1.1Pcn mutation (0 available); any Tslp mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit reduced atopic dermatitis-like symptoms when treated with MC903 compared to similarly treated wild-type mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory