All Phenotypes Col1a1<tm1(CAG-EGFR)Char> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Col1a1^{tm1(CAG-EGFR)Char}
targeted mutation 1, Al Charest
MGI:3837824

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Col1a1^{tm1(CAG-EGFR)Char}/Col1a1^{tm1(CAG-EGFR)Char} Pten^tm1Hwu/Pten^tm1Hwu	involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL	MGI:3837855
cn2	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Col1a1^{tm1(CAG-EGFR)Char}/Col1a1^{tm2(CAG-EGFR*)Char} Pten^tm1Hwu/Pten^tm1Hwu	involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL	MGI:3837857

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Col1a1^{tm1(CAG-EGFR)Char}/Col1a1^{tm1(CAG-EGFR)Char} Pten^tm1Hwu/Pten^tm1Hwu
Genetic Background	involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (67 available)
Col1a1^{tm1(CAG-EGFR)Char} mutation (1 available); any Col1a1 mutation (163 available)
Pten^tm1Hwu mutation (16 available); any Pten mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:146494 )

• 10% of mice die from glioblastoma multiforme development following intracranial injection of an adenoviral cre unlike similarly treated Col1a1^{tm1(CAG-EGFR)Char} homozygotes that do not develop tumors

neoplasm

increased glioblastoma incidence ( J:146494 )

• following intracranial injection of an adenoviral cre, mice develop glioblastoma multiforme with a greater than 90% tumor-free survival past 30 weeks unlike similarly treated Col1a1^{tm1(CAG-EGFR)Char} homozygotes that do not develop tumors

nervous system

increased glioblastoma incidence ( J:146494 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
high grade glioma		DOID:3070	OMIM:PS137800	J:146494

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Col1a1^{tm1(CAG-EGFR)Char}/Col1a1^{tm2(CAG-EGFR*)Char} Pten^tm1Hwu/Pten^tm1Hwu
Genetic Background	involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (67 available)
Col1a1^{tm1(CAG-EGFR)Char} mutation (1 available); any Col1a1 mutation (163 available)
Col1a1^{tm2(CAG-EGFR*)Char} mutation (1 available); any Col1a1 mutation (163 available)
Pten^tm1Hwu mutation (16 available); any Pten mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:146494 )

• no mice surviving tumor-free beyond 15 weeks following intracranial injection of an adenoviral cre unlike similarly treated Col1a1^{tm2(CAG-EGFR*)Char} or Col1a1^{tm1(CAG-EGFR)Char} homozygotes that do not develop tumors

neoplasm

increased glioblastoma incidence ( J:146494 )

• following intracranial injection of an adenoviral cre, mice develop glioblastoma multiforme with no mice surviving tumor-free beyond 13 weeks unlike similarly treated Col1a1^{tm2(CAG-EGFR*)Char} or Col1a1^{tm1(CAG-EGFR)Char} homozygotes that do not develop tumors

nervous system

increased glioblastoma incidence ( J:146494 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
high grade glioma		DOID:3070	OMIM:PS137800	J:146494

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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