Phenotypes associated with this allele

• Allele Symbol: Ighg1^tm2Cgn
• Allele Name: targeted mutation 2, University of Cologne
• Allele ID: MGI:3837936
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ighg1^tm2Cgn/Ighg1^+	(C57BL/6 x 129P2/OlaHsd)F1	MGI:3837938

Genotype
MGI:3837938

ht1

• Allelic Composition: Ighg1^tm2Cgn/Ighg1⁺
• Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal class switch recombination ( J:146428 )

• B cells activated in vitro with LPS and IL-4 have a 95% reduction in IgG1 class switch recombination for the mutant 129P2/OlaHsd allele

• absence of class switching in these cultures leads to a doubling in the percentage of B cells expressing IgM from the 129P2/OlaHsd allele

• IgG1 class switch recombination for the wild-type C57BL/6 allele is normal in these cultures

decreased IgG1 level ( J:146428 )

• sera levels of IgG1 expressed from the mutant 129P2/OlaHsd allele (IgG1^a) is 2% of that in controls

• no antigen specific IgG1^a antibodies are detected in mice after immunization with NP antigen compared to high levels in controls

• sera levels of IgG1 expressed from the wild-type C57BL/6 allele (IgG1^b) is normal

hematopoietic system

abnormal class switch recombination ( J:146428 )

• B cells activated in vitro with LPS and IL-4 have a 95% reduction in IgG1 class switch recombination for the mutant 129P2/OlaHsd allele

• absence of class switching in these cultures leads to a doubling in the percentage of B cells expressing IgM from the 129P2/OlaHsd allele

• IgG1 class switch recombination for the wild-type C57BL/6 allele is normal in these cultures

decreased IgG1 level ( J:146428 )

• sera levels of IgG1 expressed from the mutant 129P2/OlaHsd allele (IgG1^a) is 2% of that in controls

• no antigen specific IgG1^a antibodies are detected in mice after immunization with NP antigen compared to high levels in controls

• sera levels of IgG1 expressed from the wild-type C57BL/6 allele (IgG1^b) is normal