Phenotypes associated with this allele

• Allele Symbol: Hsp90b1^tm1Yarg
• Allele Name: targeted mutation 1, Yair Argon
• Allele ID: MGI:3837939
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsp90b1^tm1Yarg/Hsp90b1^tm1Yarg	B6.129X1-Hsp90b1^tm1Yarg	MGI:3837940

Genotype
MGI:3837940

hm1

• Allelic Composition: Hsp90b1^tm1Yarg/Hsp90b1^tm1Yarg
• Genetic Background: B6.129X1-Hsp90b1^tm1Yarg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:146397 )

• die between E7.5 and E8.5

embryo

abnormal developmental patterning ( J:146397 )

• fail to elongate properly leaving extra space in the yolk sac around the distal tip

• in culture embryoid bodies do cavitate but the organization of the peripheral cell layers is abnormal

abnormal germ layer development ( J:146397 )

• only occasionally show ingression of primitive ectodermal cells initiating the formation of mesoderm and only 2 of the 3 germ layers are present

abnormal endoderm development ( J:146397 )

• at E7.0 cells are cuboidal

abnormal left-right axis patterning ( J:146397 )

• lack lateral symmetry at E7.0

embryonic growth arrest ( J:146397 )

• fail to progress beyond the E6.5 stage

decreased embryo size ( J:146397 )

• smaller in size at E7.0 but not at E5.5

failure of primitive streak formation ( J:146397 )

abnormal embryonic-extraembryonic boundary morphology ( J:146397 )

• at E7.0, the junction between the epiblast and extraembryonic region is less pronounced

abnormal extraembryonic tissue morphology ( J:146397 )

absent amnion ( J:146397 )

• not formed at E7.0

absent chorion ( J:146397 )

• not formed at E7.0

absent proamniotic cavity ( J:146397 )

• at E7.0 no proamniotic cavity is evident

abnormal extraembryonic endoderm formation ( J:146397 )

• at E7.0 cells are cuboidal rather than a mix of cuboidal and columnar

• however, the parietal endoderm appears normal

cellular

abnormal cell differentiation ( J:146397 )

• in culture, embryonic stem cells fail to differentiate into muscle cells

growth/size/body

decreased embryo size ( J:146397 )

• smaller in size at E7.0 but not at E5.5