Phenotypes associated with this allele

• Allele Symbol: Cdx1^tm2Lhn
• Allele Name: targeted mutation 2, David Lohnes
• Allele ID: MGI:3837941
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdx1^tm2Lhn/Cdx1^tm2Lhn	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3837956
ht2	Cdx1^tm2Lhn/Cdx1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3837955

Genotype
MGI:3837956

hm1

• Allelic Composition: Cdx1^tm2Lhn/Cdx1^tm2Lhn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal occipital bone morphology ( J:146408 )

• 31% of mice exhibit fusion of occipitals

abnormal rib morphology ( J:146408 )

• 15% of mice exhibit an incomplete or fused rib at vertebrae 8

abnormal cervical atlas morphology ( J:146408 )

• 8% of mice exhibit an anterior arch of the atlas that is fused to V2

cervical vertebral transformation ( J:146408 )

• 100% of mice exhibit a C2 to C1 transformation

• 100% of mice exhibit a C3 to C2 transformation

• 92% of mice exhibit a C7 to C6 transformation

abnormal vertebral arch morphology ( J:146408 )

• 100% of mice exhibit a malformed C1 neural arch

• 85% of mice exhibit a malformed C2 neural arch

• 61% of mice exhibit a malformed C3 neural arch

• 38% of mice exhibit a neural arch fusion of vertebrae 1 and 2

• 66% of mice exhibit a neural arch fusion of vertebrae 1, 2, and 3

craniofacial

abnormal occipital bone morphology ( J:146408 )

• 31% of mice exhibit fusion of occipitals

Genotype
MGI:3837955

ht2

• Allelic Composition: Cdx1^tm2Lhn/Cdx1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

skeleton

abnormal cervical atlas morphology ( J:146408 )

• 13% of mice exhibit an anterior arch of the atlas that is fused to V2

cervical vertebral transformation ( J:146408 )

• 40% of mice exhibit a C2 to C1 transformation

abnormal vertebral arch morphology ( J:146408 )

• 13% of mice exhibit a malformed C2 neural arch