Phenotypes associated with this allele

• Allele Symbol: Cdx1^tm3Lhn
• Allele Name: targeted mutation 3, David Lohnes
• Allele ID: MGI:3837942
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdx1^tm3Lhn/Cdx1^tm3Lhn	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3837958
ht2	Cdx1^tm3Lhn/Cdx1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3837957

Genotype
MGI:3837958

hm1

• Allelic Composition: Cdx1^tm3Lhn/Cdx1^tm3Lhn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal occipital bone morphology ( J:146408 )

• 67% of mice exhibit fusion of occipitals

abnormal cervical atlas morphology ( J:146408 )

• 33% of mice exhibit an anterior arch of the atlas that is fused to V2

cervical vertebral transformation ( J:146408 )

• 100% of mice exhibit a C2 to C1 transformation

• 92% of mice exhibit a C3 to C2 transformation

• 83% of mice exhibit a C7 to C6 transformation

abnormal vertebral arch morphology ( J:146408 )

• 100% of mice exhibit a malformed C1 neural arch

• 83% of mice exhibit a malformed C2 neural arch

• 58% of mice exhibit a malformed C3 neural arch

• 17% of mice exhibit a neural arch fusion of vertebrae 1 and 2

• 33% of mice exhibit a neural arch fusion of vertebrae 1, 2, and 3

craniofacial

abnormal occipital bone morphology ( J:146408 )

• 67% of mice exhibit fusion of occipitals

Genotype
MGI:3837957

ht2

• Allelic Composition: Cdx1^tm3Lhn/Cdx1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

skeleton

abnormal cervical atlas morphology ( J:146408 )

• 42% of mice exhibit an anterior arch of the atlas that is fused to V2

cervical vertebral transformation ( J:146408 )

• 42% of mice exhibit an anterior arch of the atlas that is fused to V2

abnormal vertebral arch morphology ( J:146408 )

• 12% of mice exhibit a malformed C2 neural arch

• 6% of mice exhibit a neural arch fusion of vertebrae 1 and 2