Phenotypes associated with this allele

• Allele Symbol: Clic4^tm1Jce
• Allele Name: targeted mutation 1, John C Edwards
• Allele ID: MGI:3838012
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clic4^tm1Jce/Clic4^tm1Jce	involves: 129S1/Sv * CD-1	MGI:3838013

Genotype
MGI:3838013

hm1

• Allelic Composition: Clic4^tm1Jce/Clic4^tm1Jce
• Genetic Background: involves: 129S1/Sv * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:146487 )

• fewer than expected homozygous mice are found

cardiovascular system

abnormal vascular endothelial cell morphology ( J:146487 )

• cultured cells show an increase in the number of multivacuolated cells and a decrease in the number of vacuolated cells

abnormal retina vasculature morphology ( J:146487 )

• at P4 while the area covered by the advancing retinal tree is comparable to wild-type controls tip cells containing large intracellular vacuole are more common and multivacuolated structures are more frequently found behind the front of the expanding vascular tree

• at P7 the radial fraction of the vascular network to the retinal as a whole is reduced suggesting a delay in vascular development

• at P21 the retinal vascular tree is less dense and less complex compared to wild-type controls

abnormal angiogenesis ( J:146487 )

• formation of blood filled vessels is decreased by about 60% in matrigel plug assays

abnormal physiological neovascularization ( J:146487 )

• retinal vascular regrowth following high oxygen exposure is reduced compared to controls

decreased angiogenesis ( J:146487 )

• formation of blood filled vessels is decreased by about 60% in matrigel plug assays

abnormal vascular endothelial cell physiology ( J:146487 )

• average pH of large vacuoles is increased indicating a defect in acidification of these vacuoles

reproductive system

reduced female fertility ( J:146487 )

♀ • females show an increase in the occurrence of stillbirths independent of the genotype of the pups

growth/size/body

decreased body weight ( J:146487 )

• males weigh significantly less than control males

vision/eye

abnormal retina vasculature morphology ( J:146487 )

• at P4 while the area covered by the advancing retinal tree is comparable to wild-type controls tip cells containing large intracellular vacuole are more common and multivacuolated structures are more frequently found behind the front of the expanding vascular tree

• at P7 the radial fraction of the vascular network to the retinal as a whole is reduced suggesting a delay in vascular development

• at P21 the retinal vascular tree is less dense and less complex compared to wild-type controls