Phenotypes associated with this allele

• Allele Symbol: Del(11Nme2-Nme1)1Zou
• Allele Name: deletion, Chr 11, Xiaoming Zou 1
• Allele ID: MGI:3838141
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(11Nme2-Nme1)1Zou/Del(11Nme2-Nme1)1Zou	involves: 129 * C57BL/6	MGI:3838143

Genotype
MGI:3838143

hm1

• Allelic Composition: Del(11Nme2-Nme1)1Zou/Del(11Nme2-Nme1)1Zou
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:146219 )

• born alive but die within minutes of birth

hematopoietic system

hematopoietic system phenotype ( J:146219 )

N • leukocytes are present in normal numbers in the periphery

N • despite defects in erythropoiesis globin RNA expression is normal

extramedullary hematopoiesis ( J:146219 )

• in liver

• predominantly erythropoietic

anemia ( J:146219 )

• progressive anemia starting after E14.5

• profoundly anemic at E17.5

decreased erythrocyte cell number ( J:146219 )

• peripheral blood smears are hypocellular and contain increased numbers of nucleated erythroid precursors including prorubicytes, rubricytes, and metarubricytes

• decrease in total blood count and red cell count

decreased hematocrit ( J:146219 )

decreased hemoglobin content ( J:146219 )

increased nucleated erythrocyte cell number ( J:146219 )

• large numbers of nucleated red cells are found in mice at E18.5

anisocytosis ( J:146219 )

• increased red cell distribution width

decreased hematopoietic stem cell number ( J:146219 )

• islands of hematopoietic cells are present in the bone marrow but are smaller and less cellular compared to controls

homeostasis/metabolism

abnormal circulating iron level ( J:146219 )

• abnormal distribution of iron between serum and blood cells with a relative increase in the amount of iron found in the serum

decreased circulating iron level ( J:146219 )

abnormal circulating protein level ( J:146219 )

• reduction in blood heme levels correlating to reduction in cellular iron levels

embryo

decreased embryo size ( J:146219 )

• embryos and neonates are 3 to 5 fold smaller

• reduction in size becomes visible after E14.5

growth/size/body

decreased embryo size ( J:146219 )

• embryos and neonates are 3 to 5 fold smaller

• reduction in size becomes visible after E14.5

integument

pallor ( J:146219 )

• seen in embryos and neonates after E14.5