Phenotypes associated with this allele

• Allele Symbol: Snai1^tm1.1Stjw
• Allele Name: targeted mutation 1.1, Stephen Weiss
• Allele ID: MGI:3838175
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Snai1^tm1.1Stjw/Snai1^+	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:3838177
cn2	Snai1^tm1.1Stjw/Snai1^tm1.1Stjw Twist2^tm1.1(cre)Dor/Twist2^+	B6.129(SJL)-Twist2^tm1.1(cre)Dor Snai1^tm1.1Stjw	MGI:5659658
cn3	Snai1^tm1.1Stjw/Snai1^tm1.1Stjw Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	B6.Cg-Snai1^tm1.1Stjw Commd10^Tg(Vav1-icre)A2Kio	MGI:5659610
cn4	Snai1^tm1.1Stjw/Snai1^tm1.1Stjw Tg(Tek-cre)1Ywa/0	B6.Cg-Snai1^tm1.1Stjw Tg(Tek-cre)1Ywa	MGI:5659607

Genotype
MGI:3838177

cn1

• Allelic Composition: Snai1^tm1.1Stjw/Snai1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:146645 )

• adenovirus cre-treated fibroblasts on a chorioallantoic membrane exhibit reduced ability to induce neovessel formation compared to wild-type cells

abnormal cell migration ( J:146645 )

• adenovirus cre-treated fibroblasts exhibit decreased invasiveness of a chorioallantoic membrane compared to wild-type cells

Genotype
MGI:5659658

cn2

• Allelic Composition: Snai1^tm1.1Stjw/Snai1^tm1.1Stjw; Twist2^{tm1.1(cre)Dor}/Twist2⁺
• Genetic Background: B6.129(SJL)-Twist2^{tm1.1(cre)Dor} Snai1^tm1.1Stjw

normal phenotype

no abnormal phenotype detected ( J:214991 )

• viable with no gross abnormalities at E14.5 and P1

Genotype
MGI:5659610

cn3

• Allelic Composition: Snai1^tm1.1Stjw/Snai1^tm1.1Stjw; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: B6.Cg-Snai1^tm1.1Stjw Commd10^{Tg(Vav1-icre)A2Kio}

normal phenotype

no abnormal phenotype detected ( J:214991 )

• viable with no gross abnormalities at E14.5, E17.5 and P1

• hematopoietic progenitors from E9.5 embryos demonstrate comparable erythroid colony formation

Genotype
MGI:5659607

cn4

• Allelic Composition: Snai1^tm1.1Stjw/Snai1^tm1.1Stjw; Tg(Tek-cre)1Ywa/0
• Genetic Background: B6.Cg-Snai1^tm1.1Stjw Tg(Tek-cre)1Ywa

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:214991 )

• by E11.5 and E12.5, approximately 50 and 100% of mice die, respectively

cardiovascular system

abnormal brain vasculature morphology ( J:214991 )

• cranial blood vessels fail to undergo remodeling events

abnormal placental labyrinth vasculature morphology ( J:214991 )

• decreased vascularization with fewer fetal blood vessels invading

abnormal angiogenesis ( J:214991 )

abnormal developmental vascular remodeling ( J:214991 )

• cranial blood vessels fail to undergo remodeling events

• at E11.5 about 50% of embryos are necrotic with no intact vascular structures

abnormal vascular branching morphogenesis ( J:214991 )

• intersomitic vessels form but are unable to organize or full infiltrate the somites, displaying significant decreases in vessel length and branch points

decreased angiogenesis ( J:214991 )

• impaired vascularization of the tail with the formation of truncated and disorganized networks

decreased atrioventricular cushion size ( J:214991 )

• decrease in the number of mesenchymal cells in the atrioventricular canal

embryo

abnormal placental labyrinth vasculature morphology ( J:214991 )

• decreased vascularization with fewer fetal blood vessels invading

decreased embryo size ( J:214991 )

• at E10.5 and E11.5 crown to rump length is decreased by 32 and 47%, respectively, compared to control littermates

thin placenta labyrinth ( J:214991 )

abnormal vitelline vascular remodeling ( J:214991 )

• severely defective remodeling of the primary vascular plexus at E10.5

growth/size/body

decreased embryo size ( J:214991 )

• at E10.5 and E11.5 crown to rump length is decreased by 32 and 47%, respectively, compared to control littermates

nervous system

abnormal brain vasculature morphology ( J:214991 )

• cranial blood vessels fail to undergo remodeling events