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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cr1ltm1.1Song
targeted mutation 1.1, Wen-Chao Song
MGI:3838179
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cr1ltm1.1Song/Cr1ltm1.1Song
Tg(Cd4-cre)1Cwi/0 		involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL MGI:3838224
cn2
 		Cr1ltm1.1Song/Cr1ltm1.1Song
Tg(Lck-cre)548Jxm/0 		involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL MGI:3838225
cn3
 		Cr1ltm1.1Song/Cr1ltm1.1Song
Vsig4tm1Gne/Vsig4tm1Gne
Tg(Cd4-cre)1Cwi/0 		involves: 129S6/SvEvTac * C57BL/6N * DBA/2 * SJL MGI:3838226


Genotype
MGI:3838224
cn1
Allelic
Composition		 Cr1ltm1.1Song/Cr1ltm1.1Song
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr1ltm1.1Song mutation (0 available); any Cr1l mutation (30 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:146538 )
• in the peripheral blood
decreased lymphocyte cell number ( J:146538 )
• mice exhibit T cell lymphopenia
decreased CD4-positive, alpha-beta T cell number ( J:146538 )
• CD4+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice
• however, thymic CD4+ counts are normal
decreased CD8-positive, alpha-beta T cell number ( J:146538 )
• CD8+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice
• however, thymic CD8+ counts are normal

hematopoietic system
increased B cell number ( J:146538 )
• in the peripheral blood
decreased lymphocyte cell number ( J:146538 )
• mice exhibit T cell lymphopenia
decreased CD4-positive, alpha-beta T cell number ( J:146538 )
• CD4+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice
• however, thymic CD4+ counts are normal
decreased CD8-positive, alpha-beta T cell number ( J:146538 )
• CD8+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice
• however, thymic CD8+ counts are normal




Genotype
MGI:3838225
cn2
Allelic
Composition		 Cr1ltm1.1Song/Cr1ltm1.1Song
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr1ltm1.1Song mutation (0 available); any Cr1l mutation (30 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:146538 )
• in the peripheral blood
decreased lymphocyte cell number ( J:146538 )
• mice exhibit T cell lymphopenia
• however, chemical depletion of macrophages ameliorates T cell lymphopenia
decreased CD4-positive, alpha-beta T cell number ( J:146538 )
• CD4+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice
• however, thymic CD4+ counts are normal
decreased CD8-positive, alpha-beta T cell number ( J:146538 )
• CD8+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice
• however, thymic CD8+ counts are normal

hematopoietic system
increased B cell number ( J:146538 )
• in the peripheral blood
decreased lymphocyte cell number ( J:146538 )
• mice exhibit T cell lymphopenia
• however, chemical depletion of macrophages ameliorates T cell lymphopenia
decreased CD4-positive, alpha-beta T cell number ( J:146538 )
• CD4+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice
• however, thymic CD4+ counts are normal
decreased CD8-positive, alpha-beta T cell number ( J:146538 )
• CD8+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice
• however, thymic CD8+ counts are normal




Genotype
MGI:3838226
cn3
Allelic
Composition		 Cr1ltm1.1Song/Cr1ltm1.1Song
Vsig4tm1Gne/Vsig4tm1Gne
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr1ltm1.1Song mutation (0 available); any Cr1l mutation (30 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Vsig4tm1Gne mutation (0 available); any Vsig4 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased lymphocyte cell number ( J:146538 )
• mice exhibit peripheral T cell lymphopenia

immune system
decreased lymphocyte cell number ( J:146538 )
• mice exhibit peripheral T cell lymphopenia




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory