About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cr1ltm1.1Song
targeted mutation 1.1, Wen-Chao Song
MGI:3838179
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cr1ltm1.1Song/Cr1ltm1.1Song
Tg(Cd4-cre)1Cwi/0 		involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL MGI:3838224
cn2
 		Cr1ltm1.1Song/Cr1ltm1.1Song
Tg(Lck-cre)548Jxm/0 		involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL MGI:3838225
cn3
 		Cr1ltm1.1Song/Cr1ltm1.1Song
Vsig4tm1Gne/Vsig4tm1Gne
Tg(Cd4-cre)1Cwi/0 		involves: 129S6/SvEvTac * C57BL/6N * DBA/2 * SJL MGI:3838226


Genotype
MGI:3838224
cn1
Allelic
Composition		 Cr1ltm1.1Song/Cr1ltm1.1Song
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr1ltm1.1Song mutation (0 available); any Cr1l mutation (30 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:146538 )
• in the peripheral blood
decreased lymphocyte cell number ( J:146538 )
• mice exhibit T cell lymphopenia
decreased CD4-positive, alpha-beta T cell number ( J:146538 )
• CD4+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice
• however, thymic CD4+ counts are normal
decreased CD8-positive, alpha-beta T cell number ( J:146538 )
• CD8+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice
• however, thymic CD8+ counts are normal

hematopoietic system
increased B cell number ( J:146538 )
• in the peripheral blood
decreased lymphocyte cell number ( J:146538 )
• mice exhibit T cell lymphopenia
decreased CD4-positive, alpha-beta T cell number ( J:146538 )
• CD4+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice
• however, thymic CD4+ counts are normal
decreased CD8-positive, alpha-beta T cell number ( J:146538 )
• CD8+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice
• however, thymic CD8+ counts are normal




Genotype
MGI:3838225
cn2
Allelic
Composition		 Cr1ltm1.1Song/Cr1ltm1.1Song
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr1ltm1.1Song mutation (0 available); any Cr1l mutation (30 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:146538 )
• in the peripheral blood
decreased lymphocyte cell number ( J:146538 )
• mice exhibit T cell lymphopenia
• however, chemical depletion of macrophages ameliorates T cell lymphopenia
decreased CD4-positive, alpha-beta T cell number ( J:146538 )
• CD4+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice
• however, thymic CD4+ counts are normal
decreased CD8-positive, alpha-beta T cell number ( J:146538 )
• CD8+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice
• however, thymic CD8+ counts are normal

hematopoietic system
increased B cell number ( J:146538 )
• in the peripheral blood
decreased lymphocyte cell number ( J:146538 )
• mice exhibit T cell lymphopenia
• however, chemical depletion of macrophages ameliorates T cell lymphopenia
decreased CD4-positive, alpha-beta T cell number ( J:146538 )
• CD4+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice
• however, thymic CD4+ counts are normal
decreased CD8-positive, alpha-beta T cell number ( J:146538 )
• CD8+ T cells are reduced in the spleens, lymph nodes, and peripheral blood mononuclear cells compared to in wild-type mice
• however, thymic CD8+ counts are normal




Genotype
MGI:3838226
cn3
Allelic
Composition		 Cr1ltm1.1Song/Cr1ltm1.1Song
Vsig4tm1Gne/Vsig4tm1Gne
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr1ltm1.1Song mutation (0 available); any Cr1l mutation (30 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Vsig4tm1Gne mutation (0 available); any Vsig4 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased lymphocyte cell number ( J:146538 )
• mice exhibit peripheral T cell lymphopenia

immune system
decreased lymphocyte cell number ( J:146538 )
• mice exhibit peripheral T cell lymphopenia




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory