Phenotypes associated with this allele

• Allele Symbol: Ttr^tm1Kymm
• Allele Name: targeted mutation 1, Ken-ichi Yamamura
• Allele ID: MGI:3838181
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ttr^tm1Kymm/Ttr^tm1Kymm	B6.Cg-Ttr^tm1Kymm	MGI:3838186

Genotype
MGI:3838186

hm1

• Allelic Composition: Ttr^tm1Kymm/Ttr^tm1Kymm
• Genetic Background: B6.Cg-Ttr^tm1Kymm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating thyroxine level ( J:146510 )

• circulating T4 levels are decreased by over 35% compared to controls

decreased circulating triiodothyronine level ( J:146510 )

• circulating levels of T3 are slightly decreased in the blood

abnormal circulating protein level ( J:146510 )

• mice lack transthyretin complexes in the blood

• circulating retinol binding protein levels are reduced by around 60%

abnormal retinol level ( J:146510 )

• serum retinol levels are reduced by around 95% compared to controls