All Phenotypes Hcn2<ap> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hcn2^ap/Hcn2^ap	DW/Pas-Hcn2^ap	MGI:3838313
hm2	Hcn2^ap/Hcn2^ap	involves: C57BL/6J * DW/Pas	MGI:5140001
ht3	Hcn2^ap/Hcn2⁺	DW/Pas-Hcn2^ap	MGI:3838314

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:146530 )

• some mice die after episodes of rhythmic jumping or tonic-clonic seizure

• 13.5% of mice die between 21 and 28 days after which mortality is about 10% per month until 12 months when all mice are dead

behavior/neurological

abnormal emotion/affect behavior ( J:146530 )

• by 6 months of age, mice become less interactive with littermates and their environment compared to wild-type mice

tremors ( J:146530 )

• intention tremors as mice ambulate

impaired balance ( J:146530 )

• mice fall when standing on hind legs to feed unlike wild-type mice

• all mice fall from a rotarod, but female mice exhibit more time on the rotarod than males

abnormal posture ( J:146530 )

• mice older than 4 months exhibit unusual postures in which they curl up on their side unlike wild-type mice

abnormal locomotor coordination ( J:146530 )

• mice exhibit impaired motor coordination

ataxia ( J:146530 )

impaired swimming ( J:146530 )

• mice exhibit difficulty coordinating the movement needed to swim and will drown if not assisted

abnormal gait ( J:146530 )

• unsteady

decreased locomotor activity ( J:146530 )

• by 6 months of age

increased stereotypic behavior ( J:146530 )

• mice exhibit frequent episodes of brief behavioral arrest lasting 2 to 3 seconds and occasional repeated and rhythmic jumping towards the top of the cage on their hind legs followed by a period of quiescence unlike wild-type mice

• however, mice cease their abnormal jumping behavior by 6 weeks of age

tonic-clonic seizures ( J:146530 )

• mice exhibit rare frank tonic-clonic convulsions that are followed by a period of quiescence unlike wild-type mice

absence seizures ( J:146530 )

• mice exhibit frequent, large amplitude runs of spike-wave discharges often associated with a head twitch or behavioral pause unlike wild-type mice

• mice exhibit absence seizures that can be eliminate by treatment with ethosuximide

abnormal spike wave discharge ( J:146530 )

• mice exhibit frequent, large amplitude runs of spike-wave discharges often associated with a head twitch or behavioral pause unlike wild-type mice

growth/size/body

decreased body weight ( J:146530 )

• at P14

decreased body length ( J:146530 )

• at P14

nervous system

tonic-clonic seizures ( J:146530 )

• mice exhibit rare frank tonic-clonic convulsions that are followed by a period of quiescence unlike wild-type mice

absence seizures ( J:146530 )

• mice exhibit frequent, large amplitude runs of spike-wave discharges often associated with a head twitch or behavioral pause unlike wild-type mice

• mice exhibit absence seizures that can be eliminate by treatment with ethosuximide

abnormal spike wave discharge ( J:146530 )

• mice exhibit frequent, large amplitude runs of spike-wave discharges often associated with a head twitch or behavioral pause unlike wild-type mice

Allelic Composition	Hcn2^ap/Hcn2^ap
Genetic Background	involves: C57BL/6J * DW/Pas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcn2^ap mutation (0 available); any Hcn2 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:173355 )

• mice exhibit reduced viability compared with wild-type mice

reproductive system

infertility ( J:173355 )

behavior/neurological

decreased food intake ( J:173355 )

abnormal depression-related behavior ( J:173355 )

• mice exhibit less time immobile in a tail suspension test compared with wild-type mice

impaired coordination ( J:173355 )

impaired swimming ( J:173355 )

• mice cannot swim unlike wild-type mice

decreased locomotor activity ( J:173355 )

• mice exhibit reduced spontaneous movement compared with wild-type mice

growth/size/body

decreased body size ( J:173355 )

Allelic Composition	Hcn2^ap/Hcn2⁺
Genetic Background	DW/Pas-Hcn2^ap

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcn2^ap mutation (0 available); any Hcn2 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:146530 )

• all mice treated with 4-aminopyridine develop seizures with shortened latency to initiation of limb clonus and generalized myoclonus and decreased duration of generalized myoclonus and tonic-clonic phases compared to similarly treated wild-type mice

absence seizures ( J:146530 )

• 2 of 10 mice exhibit spontaneous, paroxysmal 1 to 3 second runs of spike-wave discharges associated with behavioral arrest unlike in wild-type mice

abnormal spike wave discharge ( J:146530 )

• 2 of 10 mice exhibit spontaneous, paroxysmal 1 to 3 second runs of spike-wave discharges associated with behavioral arrest unlike in wild-type mice

nervous system

increased susceptibility to pharmacologically induced seizures ( J:146530 )

absence seizures ( J:146530 )

• 2 of 10 mice exhibit spontaneous, paroxysmal 1 to 3 second runs of spike-wave discharges associated with behavioral arrest unlike in wild-type mice

abnormal spike wave discharge ( J:146530 )

• 2 of 10 mice exhibit spontaneous, paroxysmal 1 to 3 second runs of spike-wave discharges associated with behavioral arrest unlike in wild-type mice

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