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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mfngtm1Cjg
targeted mutation 1, Cynthia J Guidos
MGI:3838347
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mfngtm1Cjg/Mfngtm1Cjg B6.Cg-Mfngtm1Cjg MGI:4360087
cx2
 		Lfngtm1Rjo/Lfngtm1Rjo
Mfngtm1Cjg/Mfngtm1Cjg 		B6.Cg-Lfngtm1Rjo Mfngtm1Cjg MGI:4360090


Genotype
MGI:4360087
hm1
Allelic
Composition		 Mfngtm1Cjg/Mfngtm1Cjg
Genetic
Background		 B6.Cg-Mfngtm1Cjg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfngtm1Cjg mutation (0 available); any Mfng mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal marginal zone B cell morphology ( J:146621 )
• when mutant bone marrow is mixed 1:1 with wild-type bone marrow and transferred into lethally irradiated hosts, there is a slight reduction in the number of marginal zone B cells generated compared to controls

hematopoietic system
abnormal marginal zone B cell morphology ( J:146621 )
• when mutant bone marrow is mixed 1:1 with wild-type bone marrow and transferred into lethally irradiated hosts, there is a slight reduction in the number of marginal zone B cells generated compared to controls




Genotype
MGI:4360090
cx2
Allelic
Composition		 Lfngtm1Rjo/Lfngtm1Rjo
Mfngtm1Cjg/Mfngtm1Cjg
Genetic
Background		 B6.Cg-Lfngtm1Rjo Mfngtm1Cjg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfngtm1Rjo mutation (0 available); any Lfng mutation (32 available)
Mfngtm1Cjg mutation (0 available); any Mfng mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryonic hematopoiesis ( J:146621 )
• when mutant fetal liver cells is transferred into lethally irradiated hosts, there is a 50% reduction in the number of marginal zone B cells generated compared to controls

hematopoietic system
abnormal embryonic hematopoiesis ( J:146621 )
• when mutant fetal liver cells is transferred into lethally irradiated hosts, there is a 50% reduction in the number of marginal zone B cells generated compared to controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory