Phenotypes associated with this allele

• Allele Symbol: Acss1^tm1Jsak
• Allele Name: targeted mutation 1, Juro Sakai
• Allele ID: MGI:3838396
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Acss1^tm1Jsak/Acss1^tm1Jsak	B6.129-Acss1^tm1Jsak/Jsak	MGI:3838478

Genotype
MGI:3838478

hm1

• Allelic Composition: Acss1^tm1Jsak/Acss1^tm1Jsak
• Genetic Background: B6.129-Acss1^tm1Jsak/Jsak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:146647 )

• mice started on a low carbohydrate/high fat diet at weaning begin dying after 5 days on the diet

• after 21 days on the diet 51% are dead

• delay in starting mice on a low carbohydrate/high fat diet until 6 weeks after weaning eliminates premature lethality

growth/size/body

increased susceptibility to weight loss ( J:146647 )

• low carbohydrate/high fat diet started at weaning results in weight loss

increased growth rate ( J:146647 )

• recover the weight and length deficit relative to controls by 20 weeks of age

postnatal growth retardation ( J:146647 )

• normal body weight and length at birth

• significant growth retardation is apparent at weaning

• low carbohydrate/high fat diet started 6 weeks after weaning results in slower growth

behavior/neurological

abnormal food intake ( J:146647 )

• low at 4 weeks of age

• normal at 20 weeks of age

homeostasis/metabolism

impaired adaptive thermogenesis ( J:146647 )

• reduced ability to maintain core body temperature after 48 hours of fasting

• adaptive thermogenesis in response to cold is normal

abnormal blood homeostasis ( J:146647 )

hypoglycemia ( J:146647 )

• low carbohydrate/high fat diet started at weaning results in sustained hypoglycemia

decreased circulating leptin level ( J:146647 )

• at 2-4 weeks of age

abnormal circulating free fatty acids level ( J:146647 )

• considerably elevated acetate levels in plasma at 2-4 weeks of age

abnormal body temperature homeostasis ( J:146647 )

• low carbohydrate/high fat diet started at weaning results in reduced body temperature

abnormal carbon dioxide level ( J:146647 )

• arterial carbon dioxide partial pressure is significantly decreased

abnormal exercise endurance ( J:146647 )

• reduced ability of fasted animals to maintain a normal level of exercise

cellular

abnormal aerobic respiration ( J:146647 )

• acetate oxidation is severely reduced in fasted mice

• acetyl-coA levels are reduced 75%