About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdgfratm12Sor
targeted mutation 12, Philippe Soriano
MGI:3838504
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Pdgfratm12Sor/Pdgfra+ 		involves: 129 * C57BL/6 MGI:3838615
cn2
 		Cdkn2atm1Rdp/Cdkn2atm1Rdp
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Pdgfratm12Sor/Pdgfra+ 		involves: 129 * C57BL/6J * SJL MGI:3838621


Genotype
MGI:3838615
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Pdgfratm12Sor/Pdgfra+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Pdgfratm12Sor mutation (1 available); any Pdgfra mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:146617 )
• 6 months after tamoxifen treatment, mice develop intestinal disease and eventually die or are sacrificed

digestive/alimentary system
abnormal cecum morphology ( J:146617 )
• tamoxifen-treated mice exhibit partial or complete fibrosis of the small intestine and cecum unlike in wild-type mice with increased submucosal connective tissue and proportional increase in fibroblast-like cells and collagenous matrix
abnormal small intestine morphology ( J:146617 )
• tamoxifen-treated mice exhibit partial or complete fibrosis of the small intestine and cecum unlike in wild-type mice with increased submucosal connective tissue and proportional increase in fibroblast-like cells and collagenous matrix
intestinal fibrosis ( J:146617 )
• tamoxifen-treated mice exhibit partial or complete fibrosis of the small intestine and cecum unlike in wild-type mice with increased submucosal connective tissue and proportional increase in fibroblast-like cells and collagenous matrix
intestine polyps ( J:146617 )
• in tamoxifen-treated mice

cardiovascular system
cardiac fibrosis ( J:146617 )
• in tamoxifen-treated mice

renal/urinary system
glomerulosclerosis ( J:146617 )
• sclerotic glomeruli in tamoxifen-treated mice
renal glomerulus fibrosis ( J:146617 )
• in tamoxifen-treated mice
renal glomerulus hypertrophy ( J:146617 )
• enlarged glomeruli in tamoxifen-treated mice
renal interstitial fibrosis ( J:146617 )
• in tamoxifen-treated mice

neoplasm
increased sarcoma incidence ( J:146617 )
• at between 44 and 76 weeks of age, 5 of 29 tamoxifen-treated mice develop sarcomas arising from dermis or muscle connective tissue

muscle
skeletal muscle interstitial fibrosis ( J:146617 )
• in tamoxifen-treated mice

respiratory system
pulmonary fibrosis ( J:146617 )
• around the bronchioles in tamoxifen-treated mice

integument
tight skin ( J:146617 )
• in tamoxifen-treated mice




Genotype
MGI:3838621
cn2
Allelic
Composition		 Cdkn2atm1Rdp/Cdkn2atm1Rdp
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Pdgfratm12Sor/Pdgfra+
Genetic
Background		 involves: 129 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (67 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Pdgfratm12Sor mutation (1 available); any Pdgfra mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased sarcoma incidence ( J:146617 )
• all tamoxifen-treated mice develop sarcomas of the skin or muscle connective tissue after 10 to 19 weeks
increased fibrosarcoma incidence ( J:146617 )
• 2 tamoxifen-treated mice develop large intestinal tumors resembling undifferentiated fibrosarcomas

muscle
skeletal muscle interstitial fibrosis ( J:146617 )
• tamoxifen-treated mice develop muscle fibrosis at 10 to 19 weeks of age

integument
skin fibrosis ( J:146617 )
• tamoxifen-treated mice develop skin fibrosis at 10 to 19 weeks of age

digestive/alimentary system
intestinal fibrosis ( J:146617 )
• after 15 weeks, tamoxifen-treated mice exhibit intestinal fibrosis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory