All Phenotypes Gsdma3<M1Btlr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gsdma3^M1Btlr/Gsdma3^M1Btlr	either: C57BL/6J-Gsdma3^M1Btlr or (involves: C3H * C57BL/6J)	MGI:3838538
ht2	Gsdma3^M1Btlr/Gsdma3⁺	either: C57BL/6J-Gsdma3^M1Btlr or (involves: C3H * C57BL/6J)	MGI:3838537

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cornea opacity ( J:146738 )

• some homozygous mutants exhibit corneal opacity

microphthalmia ( J:146738 )

• the eyes of mutant mice appear reduced in size

craniofacial

big ears ( J:146738 )

• the pinnae of mutant mice appear larger than those of wild type littermates

hearing/vestibular/ear

big ears ( J:146738 )

• the pinnae of mutant mice appear larger than those of wild type littermates

integument

long hair ( J:146738 )

• as the coat thins, the remaining hairs gradually appear longer

progressive hair loss ( J:146738 )

• from about three weeks of age, mice heterozygous for this mutation exhibit progressive hair loss

• mutant mice eventually become entirely hairless, except for the vibrissae and snout hairs; the hair loss may be more severe in homozygous than in heterozygous mutants

• Background Sensitivity: mutant mice of the coisogenic C57BL/6J strain backgroiund are bare by 4 months of age; hair loss is relatively delayed in a mixed C3H/C57BL/6J background

coarse hair ( J:146738 )

• as the coat thins, the remaining hairs gradually appear coarser

wrinkled skin ( J:146738 )

• before three weeks of age, the hair coats of mutant mice appear normal; however, their skin is visibly wrinkled beneath the fur

growth/size/body

big ears ( J:146738 )

• the pinnae of mutant mice appear larger than those of wild type littermates

Allelic Composition	Gsdma3^M1Btlr/Gsdma3⁺
Genetic Background	either: C57BL/6J-Gsdma3^M1Btlr or (involves: C3H * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsdma3^M1Btlr mutation (1 available); any Gsdma3 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

microphthalmia ( J:146738 )

• the eyes of mutant mice appear reduced in size

craniofacial

big ears ( J:146738 )

• the pinnae of mutant mice appear larger than those of wild type littermates

hearing/vestibular/ear

big ears ( J:146738 )

• the pinnae of mutant mice appear larger than those of wild type littermates

integument

long hair ( J:146738 )

• as the coat thins, the remaining hairs gradually appear longer

progressive hair loss ( J:146738 )

• from about three weeks of age, mice heterozygous for this mutation exhibit progressive hair loss

• mutant mice eventually become entirely hairless, except for the vibrissae and snout hairs; the hair loss may be less severe in heterozygous than in homozygous mutants

• Background Sensitivity: mutant mice of the coisogenic C57BL/6J strain backgroiund are bare by 4 months of age; hair loss is relatively delayed in a mixed C3H/C57BL/6J background

coarse hair ( J:146738 )

• as the coat thins, the remaining hairs gradually appear coarser

wrinkled skin ( J:146738 )

• before three weeks of age, the hair coats of mutant mice appear normal; however, their skin is visibly wrinkled beneath the fur

growth/size/body

big ears ( J:146738 )

• the pinnae of mutant mice appear larger than those of wild type littermates

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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