Phenotypes associated with this allele

• Allele Symbol: Pdgfra^tm13.1Sor
• Allele Name: targeted mutation 13.1, Philippe Soriano
• Allele ID: MGI:3838516
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pdgfra^tm13.1Sor/Pdgfra^+	involves: 129 * C57BL/6	MGI:3838618

Genotype
MGI:3838618

ht1

• Allelic Composition: Pdgfra^tm13.1Sor/Pdgfra⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:146617 )

• while mice are present in Mendelian ratios at E18.5, fewer than expected mice are present at P14

renal/urinary system

abnormal kidney pelvis morphology ( J:146617 )

• as early as E16.5 the renal pelvis is enlarged unlike in wild-type mice

hydronephrosis ( J:146617 )

• mice develop bilateral hydronephrosis unlike in wild-type mice

abnormal ureter morphology ( J:146617 )

• mice exhibit stromal hyperplasia in the ureter unlike in wild-type mice

abnormal ureter smooth muscle morphology ( J:146617 )

• ureters exhibit poorly condensed smooth muscle cells unlike in wild-type mice

dilated ureter ( J:146617 )

ureter obstruction ( J:146617 )

• due to stromal cell hyperplasia

digestive/alimentary system

esophagus hyperplasia ( J:146617 )

• stromal cell hyperplasia

abnormal stomach morphology ( J:146617 )

• mice exhibit hyperplasia of stromal cells in the stomach

cellular

increased fibroblast proliferation ( J:146617 )

• in culture, primary fibroblasts exhibit increased growth potential compared to wild-type cells

growth/size/body

esophagus hyperplasia ( J:146617 )

• stromal cell hyperplasia