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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Epb41l2tm1.1Aliv
targeted mutation 1.1, Aleksandra Ivanovic
MGI:3838853
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Epb41l2tm1.1Aliv/Epb41l2tm1.1Aliv involves: 129P2/OlaHsd * FVB/N MGI:3838875
cx2
 		Epb41l1tm1.1Aliv/Epb41l1tm1.1Aliv
Epb41l2tm1.1Aliv/Epb41l2tm1.1Aliv 		involves: 129P2/OlaHsd * FVB/N MGI:3838877


Genotype
MGI:3838875
hm1
Allelic
Composition		 Epb41l2tm1.1Aliv/Epb41l2tm1.1Aliv
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epb41l2tm1.1Aliv mutation (0 available); any Epb41l2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:146603 )
• mice exhibit no obvious abnormalities




Genotype
MGI:3838877
cx2
Allelic
Composition		 Epb41l1tm1.1Aliv/Epb41l1tm1.1Aliv
Epb41l2tm1.1Aliv/Epb41l2tm1.1Aliv
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epb41l1tm1.1Aliv mutation (0 available); any Epb41l1 mutation (165 available)
Epb41l2tm1.1Aliv mutation (0 available); any Epb41l2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:146603 )
N
• despite altered glutamatergic receptor levels, mice exhibit normal glutamatergic synapse formation, paired pulse facilitation, synaptic and extrasynaptic AMPAR responses, and long-term potentiation
decreased brain size ( J:146603 )
• at 3 weeks, brain volume is slightly decreased compared to in wild-type mice
• however, by 7 months of age mice exhibit normal brain volume
small cerebellum ( J:146603 )
• at 3 weeks, cerebellar volume is slightly decreased compared to in wild-type mice
• however, by 7 months of age mice exhibit normal cerebellar volume




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory