About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eif2s2Gt(XH413)Byg
gene trap XH413, BayGenomics
MGI:3838881
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Eif2s2Gt(XH413)Byg/Eif2s2Gt(XH413)Byg involves: 129P2/OlaHsd MGI:3838975
ht2
 		Eif2s2Gt(XH413)Byg/Eif2s2+ 129-Eif2s2Gt(XH413)Byg Chr 19MOLF/Ei MGI:3838974


Genotype
MGI:3838975
hm1
Allelic
Composition		 Eif2s2Gt(XH413)Byg/Eif2s2Gt(XH413)Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s2Gt(XH413)Byg mutation (0 available); any Eif2s2 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3838974
ht2
Allelic
Composition		 Eif2s2Gt(XH413)Byg/Eif2s2+
Genetic
Background		 129-Eif2s2Gt(XH413)Byg Chr 19MOLF/Ei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s2Gt(XH413)Byg mutation (0 available); any Eif2s2 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:146879 )
N
• despite reduced proliferation of primordial germ cells, mice exhibit normal initial spermatogonial stem cell populations and spermatogenesis
decreased primordial germ cell proliferation ( J:146879 )
• at E16.5, proliferation of primordial germ cells is less than in 129S1/SvImJ-Chr 19/Na mice
• however, the total number of germ cells in the testes at E14.5 and E16.5 is the same as in 129S1/SvImJ-Chr 19/Na mice
decreased testis weight ( J:146879 )
• compared to in 129S1/SvImJ-Chr 19/Na mice at 6 weeks of age
decreased litter size ( J:146879 )
• compared to in 129S1/SvImJ-Chr 19/Na mice

neoplasm
decreased incidence of induced tumors ( J:146879 )
• incidence of testicular germ cell tumors is decreased 2-fold compared to in 129S1/SvImJ-Chr 19/Na mice

endocrine/exocrine glands
decreased testis weight ( J:146879 )
• compared to in 129S1/SvImJ-Chr 19/Na mice at 6 weeks of age

cellular
decreased primordial germ cell proliferation ( J:146879 )
• at E16.5, proliferation of primordial germ cells is less than in 129S1/SvImJ-Chr 19/Na mice
• however, the total number of germ cells in the testes at E14.5 and E16.5 is the same as in 129S1/SvImJ-Chr 19/Na mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory