All Phenotypes Eif2s2<Gt(XH413)Byg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eif2s2^Gt(XH413)Byg/Eif2s2^Gt(XH413)Byg	involves: 129P2/OlaHsd	MGI:3838975
ht2	Eif2s2^Gt(XH413)Byg/Eif2s2⁺	129-Eif2s2^Gt(XH413)Byg Chr 19^MOLF/Ei	MGI:3838974

Allelic Composition	Eif2s2^Gt(XH413)Byg/Eif2s2^Gt(XH413)Byg
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s2^Gt(XH413)Byg mutation (0 available); any Eif2s2 mutation (96 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:146879 )

• no mice are found at E8.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:146879 )

N	• despite reduced proliferation of primordial germ cells, mice exhibit normal initial spermatogonial stem cell populations and spermatogenesis

decreased primordial germ cell proliferation ( J:146879 )

• at E16.5, proliferation of primordial germ cells is less than in 129S1/SvImJ-Chr 19/Na mice

• however, the total number of germ cells in the testes at E14.5 and E16.5 is the same as in 129S1/SvImJ-Chr 19/Na mice

decreased testis weight ( J:146879 )

• compared to in 129S1/SvImJ-Chr 19/Na mice at 6 weeks of age

decreased litter size ( J:146879 )

• compared to in 129S1/SvImJ-Chr 19/Na mice

neoplasm

decreased incidence of induced tumors ( J:146879 )

• incidence of testicular germ cell tumors is decreased 2-fold compared to in 129S1/SvImJ-Chr 19/Na mice

endocrine/exocrine glands

decreased testis weight ( J:146879 )

• compared to in 129S1/SvImJ-Chr 19/Na mice at 6 weeks of age

cellular

decreased primordial germ cell proliferation ( J:146879 )

• at E16.5, proliferation of primordial germ cells is less than in 129S1/SvImJ-Chr 19/Na mice

• however, the total number of germ cells in the testes at E14.5 and E16.5 is the same as in 129S1/SvImJ-Chr 19/Na mice

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